Association of ADAM33 gene polymorphisms with asthma in the Uygur population of China.
Association of ADAM33 gene polymorphisms with asthma in the Uygur population of China.
复制标题
ADAM33基因多态性与中国维吾尔族人群哮喘的相关性
作者：
Jing Wang;Jin Wen;Mi;Yuan;Ke;Yu;Jian;Qi
哮喘是最常见的慢性呼吸道疾病之一，影响着全球3亿儿童和成人。以往的研究发现，去整合素和金属蛋白酶结构域33(ADAM33)是不同民族哮喘的重要易感基因；然而，这种关系是否存在于不同种族的人群中尚不清楚。本研究旨在探讨ADAM33基因单核苷酸多态性(SNPs)与中国维吾尔族人群哮喘的关系。采用病例对照研究方法，对中国维吾尔族成人哮喘患者和健康对照人群进行ADAM33SNP(T1、S+1和F+1)基因分型。哮喘组ADAM33T1C等位基因频率显著高于健康对照组(20.6vs.11.1%，P=0.003)。ADAM33基因在两组间的分布有显著差异。T1TC等位基因频率高于健康对照组[优势比(OR)=2.118，P=0.016]，TC+CC变异基因增加哮喘风险(OR=2.244，P=0.005)。调整混杂因素后，TC和TC+CC对哮喘的OR值分别为2.317和2.522。TC型患者的用力呼气量(FEV1)水平明显低于TT型患者。单倍型分析显示，哮喘患者Hap5(CaC)和Hap6(CAT)的频率显著高于健康对照组(P分别为0.024和0.016)。S+1和F+1单核苷酸多态在哮喘患者和对照组之间的基因频率和等位基因频率差异无统计学意义。综上所述，ADAM33T1SNP可能影响中国维吾尔族人群哮喘的易感性。
Asthma is one of the most common chronic respiratory diseases, affecting ∼300 million children and adults worldwide. Previous studies identified a disintegrin and metalloprotease domain 33 (ADAM33) as an important susceptibility gene for asthma in patients of different nationalities; however, it is unknown whether this relationship exists in ethnically diverse populations. The present study focused on the association between single-nucleotide polymorphisms (SNPs) of the ADAM33 gene and asthma in the Uygur population of China. Three SNPs of ADAM33 (T1, S+1 and F+1) were genotyped in a case-control study among the Chinese Uygur population, involving 126 adult asthmatic patients and 126 healthy controls. The frequency of the ADAM33 T1 C allele among asthma patients was significantly higher compared to healthy controls (20.6 vs. 11.1%, P=0.003). The distribution of ADAM33 genotypes differed significantly between the two groups. The frequency of the T1 TC genotype was higher among patients compared to healthy controls [odds ratio (OR)=2.118, P=0.016] and the variant genotype, TC+CC, increased the risk of asthma (OR=2.244, P=0.005). Following adjustment for confounding factors, the ORs of TC and TC+CC for asthma were 2.317 and 2.522, respectively. There was a significant decrease in the forced expiratory volume (FEV1) levels in patients with the TC genotype compared to the TT genotype of T1. Haplotype analysis revealed that the frequencies of Hap5 (CAC) and Hap6 (CAT) were significantly higher among asthmatic patients compared to healthy controls (P=0.024 and 0.016, respectively). The genotype and allele frequencies of SNP S+1 and F+1 were not statistically different between asthmatic patients and controls. In conclusion, the ADAM33 T1 SNP may affect susceptibility to asthma in the Chinese Uygur population.
影响因子：
3.5
作者：
Yoshinaka, T;Nishii, K;Higashiyama, S
通讯作者：
Higashiyama, S
影响因子：
14.2
作者：
Howard, TD;Postma, DS;Meyers, DA
通讯作者：
Meyers, DA