Acute Ethanol Exposure Enhances Synaptic Plasticity in the Dorsal Striatum in Adult Male and Female Rats.
Acute Ethanol Exposure Enhances Synaptic Plasticity in the Dorsal Striatum in Adult Male and Female Rats.
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DOI：
10.3233/bpl-190097
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发表时间：
2020-12-29
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影响因子：
--
通讯作者：
Mandyam CD
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作者：
Avchalumov Y;Piña-Crespo JC;Woodward JJ;Mandyam CD
急性（离体）和慢性（体内）酒精暴露会引起背侧纹状体的神经塑性变化，背侧纹状体是与器乐学习有关的关键区域。酒精奖励和强化方面的性别差异很明显，与雄性大鼠相比，雌性大鼠在操作范式中消耗的酒精量更高。然而，急性酒精在背侧纹状体中产生的神经塑性变化的性别差异尚未被探索。利用从成年雄性和雌性大鼠获得的背侧纹状体切片的电生理记录，我们研究了离体乙醇暴露对突触传递和突触可塑性的影响。乙醇 (44 mM) 增强了两性的基础突触传递。乙醇还增强了两性的长时程增强作用。乙醇对两种性别的突触可塑性的其他测量（包括配对脉冲比）均没有改变。结果表明，在与中毒相关的浓度下，急性乙醇引起的突触可塑性变化可能在酒精引起的皮质纹状体回路的经验依赖性改变中发挥重要作用，而皮质纹状体回路是学习目标导向的工具性行为以及介导寻求和饮酒的习惯形成的基础。总而言之，了解酒精引起的皮质纹状体功能变化的机制可能会导致开发更有效的治疗药物，以减少与酒精使用障碍相关的习惯性饮酒和寻求。
Acute (ex vivo) and chronic (in vivo) alcohol exposure induces neuroplastic changes in the dorsal striatum, a critical region implicated in instrumental learning. Sex differences are evident in alcohol reward and reinforcement, with female rats consuming higher amount of alcohol in operant paradigms compared to male rats. However, sex differences in the neuroplastic changes produced by acute alcohol in the dorsal striatum have been unexplored. Using electrophysiological recordings from dorsal striatal slices obtained from adult male and female rats, we investigated the effects of ex vivo ethanol exposure on synaptic transmission and synaptic plasticity. Ethanol (44 mM) enhanced basal synaptic transmission in both sexes. Ethanol also enhanced long-term potentiation in both sexes. Other measures of synaptic plasticity including paired-pulse ratio were unaltered by ethanol in both sexes. The results suggest that alterations in synaptic plasticity induced by acute ethanol, at a concentration associated with intoxication, could play an important role in alcohol-induced experience-dependent modification of corticostriatal circuits underlying the learning of goal-directed instrumental actions and formation of habits mediating alcohol seeking and taking. Taken together, understanding the mechanism(s) underlying alcohol induced changes in corticostriatal function may lead to the development of more effective therapeutic agents to reduce habitual drinking and seeking associated with alcohol use disorders.