Longitudinal analysis of macronutrients and minerals in human milk produced by mothers of preterm infants
Longitudinal analysis of macronutrients and minerals in human milk produced by mothers of preterm infants
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DOI：
10.1016/j.clnu.2010.08.003
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发表时间：
2011-04-01
影响因子：
6.3
通讯作者：
Gerss, Joachim
中科院分区：
文献类型：
--
作者：
Bauer, Jacqueline;Gerss, Joachim
背景与目的：本研究的主要目的是调查极早产儿(28周)母亲哺乳前8周母乳的营养成分，并对早产儿和足月乳进行比较。方法：对102名早产儿母亲和10名足月儿母亲的母乳进行纵向采集。每周对每个参与者的脂肪、蛋白质、碳水化合物、矿物质和能量含量进行评估。结果：早产儿的碳水化合物、脂肪和能量浓度显著高于足月乳(p<；0.05)。早产乳和足月乳的蛋白质含量都随着哺乳的进展而下降，极早产乳(28周)的蛋白质含量显着高于中度早产乳和足月乳(p<；0.0001)。早产乳钠水平仅在第一周显著升高(p<；0.05)。其他矿物质含量的变化在早产儿和足月乳中都没有检测到。结论：我们的数据提供了关于极早产儿母亲乳汁中常量营养素含量的新信息，可能对这一人群的营养有意义。(C)2010年爱思唯尔有限公司和欧洲临床营养与代谢学会。版权所有。
Background & aims: The primary objective of this study was to investigate the composition of breast milk of mothers with extremely preterm infants (< 28 weeks) for their nutrient content over the first 8 weeks of lactation, and to compare premature to term milk.Methods: Breast milk from 102 mothers who had delivered preterm infants and from 10 mothers who had delivered term infants were collected longitudinally. Fat, protein, carbohydrate, minerals and energy content were estimated weekly in each participant. Milk samples were representative of complete 24-h cycles.Results: Carbohydrate, fat and energy concentrations were significantly higher in preterm than in term milk (p < 0.05). Protein content of both preterm and term milk decreased with the progress of lactation demonstrating significantly higher values in extremely preterm milk (< 28 weeks) than in moderately preterm and term milk (p < 0.0001). The sodium levels of preterm milk were significantly elevated (p < 0.05) only in the first week. Other changes in mineral content were detected neither in preterm nor term milk.Conclusions: Our data provide new information on the macronutrient content of milk in mothers of extremely preterm infants with possible implications for the nutrition of this population. (C) 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.