Mesenchymal Stromal Cells and Cutaneous Wound Healing: A Comprehensive Review of the Background, Role, and Therapeutic Potential.
Mesenchymal Stromal Cells and Cutaneous Wound Healing: A Comprehensive Review of the Background, Role, and Therapeutic Potential.
复制标题
DOI：
10.1155/2018/6901983
复制
发表时间：
2018
影响因子：
4.3
通讯作者：
Wan DC
中科院分区：
文献类型：
--
作者：
Hu MS;Borrelli MR;Lorenz HP;Longaker MT;Wan DC
皮肤创伤修复是一个高度协调的级联反应损伤，恢复表皮的完整性和屏障功能。即使在最佳愈合条件下，成人皮肤的正常伤口修复也是不完美的，并且经常发生延迟愈合和瘢痕形成。伤口愈合失调是全球医疗保健的一个主要问题，鉴于糖尿病和老龄化人口的增加，这种医学经济学疾病负担将继续上升。目前还没有可靠地改善不愈合伤口和减少疤痕的治疗方法。间充质基质细胞（MSC）已成为一种强大的技术，以改善皮肤伤口愈合。它们的分化潜力、易于收获、低免疫原性和在天然伤口愈合生理学中的不可或缺的作用使MSC成为有吸引力的治疗药物。MSC促进细胞迁移、血管生成、上皮形成和肉芽组织形成，这导致加速伤口闭合。MSC鼓励再生，而不是纤维化，伤口愈合微环境。最近使用现代生物工程方法的转化研究工作在创造用于将基质细胞递送到愈合伤口中的新技术方面取得了进展。本文讨论了各种基质细胞促进伤口愈合的实验应用，并讨论了用于增加MSC递送和功效的新方法。
Cutaneous wound repair is a highly coordinated cascade of cellular responses to injury which restores the epidermal integrity and its barrier functions. Even under optimal healing conditions, normal wound repair of adult human skin is imperfect and delayed healing and scarring are frequent occurrences. Dysregulated wound healing is a major concern for global healthcare, and, given the rise in diabetic and aging populations, this medicoeconomic disease burden will continue to rise. Therapies to reliably improve nonhealing wounds and reduce scarring are currently unavailable. Mesenchymal stromal cells (MSCs) have emerged as a powerful technique to improve skin wound healing. Their differentiation potential, ease of harvest, low immunogenicity, and integral role in native wound healing physiology make MSCs an attractive therapeutic remedy. MSCs promote cell migration, angiogenesis, epithelialization, and granulation tissue formation, which result in accelerated wound closure. MSCs encourage a regenerative, rather than fibrotic, wound healing microenvironment. Recent translational research efforts using modern bioengineering approaches have made progress in creating novel techniques for stromal cell delivery into healing wounds. This paper discusses experimental applications of various stromal cells to promote wound healing and discusses the novel methods used to increase MSC delivery and efficacy.
登录
查看更多内容
DOI：
10.4049/jimmunol.1201213
发表时间：
2013-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brubaker AL;Rendon JL;Ramirez L;Choudhry MA;Kovacs EJ
通讯作者：
Kovacs EJ
影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
20.3
作者：
Beltrami, Antonio R.;Cesselli, Daniela;Beltrami, Carlo A.
通讯作者：
Beltrami, Carlo A.
影响因子：
5.2
作者：
Chiossone, Laura;Conte, Romana;Bottino, Cristina
通讯作者：
Bottino, Cristina
影响因子：
5.2
作者：
Baksh, Dolores;Yao, Raphael;Tuan, Rocky S.
通讯作者：
Tuan, Rocky S.