Caroverine in tinnitus treatment - A placebo-controlled blind study
Caroverine in tinnitus treatment - A placebo-controlled blind study
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DOI：
10.3109/00016489709114208
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发表时间：
1997-11-01
影响因子：
1.4
通讯作者：
Ehrenberger, K
中科院分区：
文献类型：
--
作者：
Denk, DM;Heinzl, H;Ehrenberger, K
本研究的目的是检查是否单次输注caroverine：奎宁衍生物，可以成功地用于治疗内耳耳鸣。豚鼠微电泳实验表明，胡萝卜素是一种有效的竞争性α-氨基-3-羟基-5-甲基-4-异恶唑酮-丙酸（AMPA）受体拮抗剂，在较高剂量时，它是一种非竞争性N-甲基-d-天冬氨酸（NMDA）受体拮抗剂。根据我们对内耳耳鸣（耳蜗-突触性耳鸣）的病理生理学的工作假设;当内毛细胞传入的突触下膜处的NMDA和AMPA受体的生理活性受到干扰时，这些形式的耳鸣发生。总共有60名假定为耳蜗-突触病理生理学的内耳耳鸣患者被纳入研究：在计算机随机化后，30名患者接受caroverine治疗，30名患者接受安慰剂治疗。对于已经发生的反应，耳鸣必须显示主观评级和心理声学测量（耳鸣匹配）的降低。在caroverine组中，63.3%在输注后立即对治疗有反应。在安慰剂组中，根据定义的成功标准，接受治疗的患者均未显示出显著应答。结果证实了我们的工作假设的耳蜗突触性耳鸣的成因。
This study was performed to examine whether a single infusion of caroverine: a quinoxaline-derivative, can be used successfully in the treatment of inner ear tinnitus. Microiontophoretical experiments in guinea-pigs have shown that caroverine acted as a potent competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazone-proprionic acid (AMPA) receptor antagonist and, in higher dosages, a non-competitive N-methyl-d-aspartate (NMDA) antagonist. According to our working hypothesis of the pathophysiology of inner ear tinnitus (cochlear-synaptic tinnitus); these forms of tinnitus occur when the physiological activity of the NMDA and AMPA receptors at the subsynaptic membranes of inner hair cell afferents is disturbed. In total, 60 patients with inner ear tinnitus of assumed cochlear-synaptic pathophysiology were included in the study: after computerized randomization, 30 were treated with caroverine and 30 with placebo. For a response to have occurred, tinnitus had to show a reduction in both subjective rating and psychoacoustic measurement (tinnitus matching). In the caroverine group, 63.3% responded to therapy immediately after the infusion. In the placebo group, none of the patients treated showed a significant response according to the defined success criteria. The results confirm our working hypothesis on the genesis of cochlear-synaptic tinnitus.