Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes
Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes
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DOI：
10.1007/s00125-007-0812-z
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发表时间：
2007-11-01
期刊：
影响因子：
8.2
通讯作者：
Park, K. S.
中科院分区：
文献类型：
--
作者：
Cho, Y. M.;Kim, J. T.;Park, K. S.
目的/假设-本研究的目的是调查暴发性1型糖尿病的患病率和新诊断的韩国patients.Methods使用数据检索从首尔国立大学医院的数据库中的疾病的临床特征，我们确定了所有新诊断的1型糖尿病患者从1999年1月1日至2006年7月31日。临床表现和实验室数据，包括诊断时检测到的胰岛自身抗体的存在下，获得的信息，通过审查医疗records.Results，我们确定了99例新诊断为1型糖尿病。7例患者（7.1%）符合暴发性1型糖尿病的标准。在发病时年龄≥ 18岁的患者中，30.4%患有暴发性1型糖尿病。患有这种糖尿病亚型的患者胰岛自身抗体检测呈阴性，发病年龄较高（中位数28 vs 10年，p < 0.001），从高血压症状发作到首次住院的持续时间明显缩短（中位数3 vs 30天，p < 0.001）比非暴发性1型糖尿病患者，并且显示出血清天冬氨酸转氨酶和淀粉酶水平升高以及胰高血糖素刺激的血清C肽反应降低的趋势。结论/解释在韩国，暴发性1型糖尿病的患病率在所有新诊断的1型糖尿病患者中为7.1%，在成人发病糖尿病患者中为30.4%。暴发型1型糖尿病患者的临床和代谢特征与日本研究报告的相似。
Aims/hypothesis The aim of this study was to investigate the prevalence of fulminant type 1 diabetes and the clinical characteristics of the disease among newly diagnosed Korean patients.Methods Using data retrieved from the Seoul National University Hospital database, we identified all patients newly diagnosed with type 1 diabetes from 1 January 1999 to 31 July 2006. Information on clinical manifestations and laboratory data, including the presence of islet autoantibodies detected at diagnosis, were obtained by reviewing medical records.Results We identified 99 patients newly diagnosed with type 1 diabetes. Seven patients (7.1%) fulfilled the criteria for fulminant type 1 diabetes. Among the patients aged >= 18 years at onset, 30.4% had fulminant type 1 diabetes. Patients with this diabetes subtype tested negative for islet autoantibodies, had a higher age of onset (median 28 vs 10 years, p < 0.001) and a markedly shorter duration from onset of hyperglycaemic symptoms to first hospital visit (median 3 vs 30 days, p < 0.001) than patients with non-fulminant type 1 diabetes, and showed trends of increased serum aspartate aminotransferase and amylase levels and a decreased glucagon-stimulated serum C-peptide response.Conclusions/interpretations In Korea, the prevalence of fulminant type 1 diabetes was 7.1% among all patients newly diagnosed with type 1 diabetes and 30.4% among patients with adult-onset diabetes. The clinical and metabolic characteristics of the patients with fulminant type 1 diabetes were similar to those reported in Japanese studies.