Cell-cell interactions: leukocyte-endothelial interactions
Cell-cell interactions: leukocyte-endothelial interactions
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DOI：
10.1097/00062752-200303000-00009
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发表时间：
2003-03-01
影响因子：
3.2
通讯作者：
Zimmerman, GA
中科院分区：
文献类型：
--
作者：
McIntyre, TM;Prescott, SM;Zimmerman, GA
白细胞与内皮细胞的相互作用是急性和慢性炎症、组织免疫监视和伤口防御和修复的早期事件。与其在宿主防御中必不可少的作用相反，失调的白细胞-内皮相互作用介导炎症组织损伤、血栓形成和其他病理后遗症。最近的观察也发现了肿瘤和镰状细胞血管病变中白细胞内皮相互作用失调。白细胞与炎症内皮细胞的相互作用是由选择素、包括脂质和趋化因子在内的信号分子、整合素及其配体和连接分子介导的。它们为生理性炎症和止血的调节以及病理综合征的失调提供了多个检查点。中性粒细胞-内皮细胞的相遇说明了炎症细胞-细胞相互作用的多步骤范式，并为中心主题的多种变化提供了基础。(C) 2003利平科特·威廉姆斯·威尔金斯。
Interactions of leukocytes with endothelial cells are early events in acute and chronic inflammation, immune surveillance of tissues, and wound defense and repair. In contrast with their requisite roles in host defense, dysregulated leukocyte-endothelial interactions mediate inflammatory tissue injury, thrombosis, and other pathologic sequelae. Recent observations also identify dysregulated leukocyte-endothelial interactions in neoplasia and sickle cell vasculopathy. Leukocyte interactions with inflamed endothelial cells are mediated by selectins, signaling molecules that include lipids and chemokines, integrins and their ligands, and junctional molecules. They provide multiple checkpoints for regulation in physiologic inflammation and hemostasis and for dysregulation in pathologic syndromes. Neutrophil-endothelial encounters illustrate a multistep paradigm for inflammatory cell-cell interactions and provide the basis for multiple variations on the central themes. (C) 2003 Lippincott Williams Wilkins.