The preferential accumulation of helper‐inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion
The preferential accumulation of helper‐inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion
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炎症病变中辅助诱导 T 淋巴细胞的优先积累：选择性内皮和同型粘附调节的证据
DOI：
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发表时间：
1988
影响因子：
5.4
通讯作者：
G. Panayi
中科院分区：
文献类型：
--
作者：
C. Pitzalis;G. Kingsley;D. Haskard;G. Panayi
导致T淋巴细胞聚集成炎性病变的机制尚不清楚。我们之前已经证明，滑液CD 4 T淋巴细胞主要是CDw 29 UCHL 1（辅助诱导细胞），很少携带识别抑制诱导亚群的CD 45 R抗原。滑膜CD 8细胞也是CDw 29 UCHL 1CD 45 R −。在本研究中，胸膜和腹膜炎性浸润的淋巴细胞显示出相似的表型模式。此外，证明了CDw 29 UCHL 1亚群比CD 45 R细胞具有更大的粘附内皮细胞和形成同型簇的能力。还显示了两个子集上LFA-1的差异表面表达，但这不能解释所证明的粘附差异。CDw 29/UCHL 1和CD 45 R细胞之间粘附性的差异可以解释CDw 29/UCHL 1细胞在炎性浸润中的优先积累，并且是取自慢性炎症部位的细胞与取自外周血的细胞之间的一些功能差异的基础。
The mechanisms which lead to the accumulation of T lymphocytes into inflammatory lesions are not clearly understood. We have previously shown that synovial CD4 T lymphocytes are mostly CDw29UCHL1 (helper‐inducer cells) and very few carry the CD45R antigen which identifies the suppressor‐inducer subset. Synovial CD8 cells are also CDw29UCHL1CD45R−. In the present study, lymphocytes from pleural and peritoneal inflammatory infiltrates were shown to have a similar phenotypic pattern. Furthermore, it was demonstrated that the CDw29UCHL1 subset had a greater ability than CD45R cells to adhere to endothelial cells and to form homotypic clusters. Differential surface expression of LFA‐1 on the two subsets was also shown, but this could not account for the demonstrated adhesion differences. Differences in adhesion between CDw29/UCHL1 and CD45R cells may explain the preferential accumulation of CDw29/UCHL1 cells in inflammatory infiltrates and underlie some of the functional differences between cells taken from sites of chronic inflammation and those from peripheral blood.
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体外结合人微血管内皮细胞的淋巴细胞的表型和功能特征。
DOI：
10.1172/jci113007
发表时间：
1987
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Bender,JR;Pardi,R;Karasek,MA;Engleman,EG
通讯作者：
Engleman,EG
佛波醇 12,13-二丁酸酯 (P(Bu)2) 处理的人血液单核细胞相互结合。
影响因子：
4.3
作者：
Patarroyo,M;Biberfeld,P;Klein,E;Klein,G
通讯作者：
Klein,G
LFA-1 膜分子在人 B 淋巴细胞同型粘附调节中的作用。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Mentzer,SJ;Gromkowski,SH;Krensky,AM;Burakoff,SJ;Martz,E
通讯作者：
Martz,E
DOI：
10.1016/0090-1229(83)90052-1
发表时间：
1983
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
Silver,RM;Redelman,D;Zvaifler,NJ
通讯作者：
Zvaifler,NJ
影响因子：
4.4
作者：
Patrick G. Beatty;J. Ledbetter;Paul J. Martin;T. Price;J. Hansen
通讯作者：
Patrick G. Beatty;J. Ledbetter;Paul J. Martin;T. Price;J. Hansen