Risk factors for neurologic impairment among very low-birth-weight infants.
Risk factors for neurologic impairment among very low-birth-weight infants.
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DOI：
10.1053/spen.2001.25228
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发表时间：
2001-06-01
影响因子：
2.7
通讯作者：
Wilson-Costello, D
中科院分区：
文献类型：
--
作者：
Wilson-Costello, D
虽然脑性瘫痪是极低出生体重幸存者中最常见的神经损伤，但其病因仍不确定。目前的研究支持产前和新生儿因素在这些极早产儿脑性瘫痪发病机制中的作用。重要的产前危险因素包括绒毛膜羊膜炎和多发性胎盘病变。母体先兆子痫可能提供神经保护。主要的新生儿危险因素包括严重的头颅超声异常，慢性肺部疾病，高胆红素血症，可能还有甲状腺功能减退。
Although cerebral palsy is the most common neurologic impairment among very low-birth-weight survivors, its etiology remains uncertain. Current research supports the role of both antenatal and neonatal factors in the pathogenesis of cerebral palsy among these extremely premature infants. Important antenatal risk factors include chorioamnionitis and multiple placental lesions. Maternal preeclampsia may provide neuroprotection. The major neonatal risk factors include severe cranial ultrasound abnormalities, chronic lung disease, hyperbilirubinemia, and possibly hypothyroxinemia.