Raised plasma fibrinogen concentration in patients with abdominal aortic aneurysm
Raised plasma fibrinogen concentration in patients with abdominal aortic aneurysm
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DOI：
10.1177/0003319706293132
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发表时间：
2006-10-01
期刊：
影响因子：
2.8
通讯作者：
Scott, Julian A.
中科院分区：
文献类型：
--
作者：
Al-Barjas, Hamad S.;Ariens, Robert;Scott, Julian A.
与腹主动脉瘤（AAA）相关的特征是存在腔内血栓（ILT）。血浆纤维蛋白原浓度升高预示血栓形成的风险更大。因此，作者评估了纤维蛋白原水平、AAA大小和ILT之间的关系。进行了一项年龄和性别匹配的病例对照研究。从110例AAA患者和110例对照组中获得人口统计学数据和血浆样本。所有受试者均接受腹部超声扫描，以确定动脉瘤的大小和ILT占据管腔的百分比。采用Clauss法测定血浆纤维蛋白原浓度。AAA患者的纤维蛋白原浓度显著高于对照组（中位数：2.89 vs 2.53 g/L; p < 0.01）。与不吸烟的AAA患者相比，目前吸烟的AAA患者的中位AAA尺寸更大（4.50 vs 4.30 cm; p < 0.04），ILT百分比更高（40% vs 30%）。纤维蛋白原与AAA大小（r = 0.323; p < 0.01）和ILT占管腔的百分比（r = 0.358; p < 0.05）呈正相关。AAA组的纤维蛋白原水平较高。作者还证明了AAA大小、ILT和纤维蛋白原浓度之间的正相关性。吸烟与较大的动脉瘤和ILT相关。纤维蛋白原可能是监测AAA进展的有用指标。
A feature associated with abdominal aortic aneurysms (AAA) is the presence of intraluminal thrombi (ILT). Elevated plasma fibrinogen concentrations predict a greater risk of thrombosis. Therefore, the authors assessed the relationship between fibrinogen levels, AAA size, and ILT. An age- and sex-matched case-control study was conducted. Demographic data and plasma samples were obtained from 110 patients with AAA and 110 controls. All subjects had an abdominal ultrasound scan to determine the size of the aneurysm and the percentage of the ILT occupying the lumen. Plasma fibrinogen concentrations were measured by the Clauss method. Fibrinogen concentrations were significantly higher in patients with AAA than in controls (median: 2.89 vs 2.53 g/L; p < 0.01). Patients with AAA who were current smokers had a larger median AAA size (4.50 vs 4.30 cm; p < 0.04) and greater percentage of the ILT (40% vs 30%) than those who did not smoke. Fibrinogen was positively correlated with AAA size (r = 0.323; p < 0.01) and the percentage of ILT occupying the lumen (r = 0.358; p < 0.05). Fibrinogen levels were higher in the AAA group. The authors also demonstrated positive correlations between the AAA size, ILT, and fibrinogen concentration. Smoking was associated with larger aneurysms and ILT. Fibrinogen may be a useful marker to monitor the progression of AAA.