The effects of hyperthermia on normal mesenchymal tissues. Application of a histologic grading system.
The effects of hyperthermia on normal mesenchymal tissues. Application of a histologic grading system.
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发表时间：
1983-06
影响因子：
4.6
通讯作者：
A. Meshorer;S. Prionas;L. F. Fajardo;J. Meyer;G. Hahn;A. Martinez
中科院分区：
文献类型：
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作者：
A. Meshorer;S. Prionas;L. F. Fajardo;J. Meyer;G. Hahn;A. Martinez
在猪的皮下脂肪组织和骨骼肌中研究了42至48摄氏度的射频诱导高温30分钟所产生的变化。急性病变（18至24小时）包括水肿、出血、坏死（主要是肌细胞）和脂肪或肌肉中的粒细胞渗出物。最重要的慢性病变（28至31天）是纤维化取代任何组织。组织淋巴细胞渗出物，大脂质空泡周围有异物巨细胞。肌肉坏死持续存在，并有可变的肌细胞再生。几个标本表现为深部坏死和肿胀。开发了一个分级系统，以独立定量每个组织中的急性和慢性损伤。急性病变的严重程度和范围通常不及慢性病变，且无明显的剂量反应。慢性病变显示出明显的剂量反应，从43摄氏度开始，并随着温度的增加而增加。后者似乎是深部软组织高温损伤的可靠指标。
The alterations produced by radiofrequency-induced hyperthermia of 42 to 48 degrees C for 30 minutes were studied in the subcutaneous adipose tissue and skeletal muscle of swine. Acute lesions (18 to 24 hours) included edema, hemorrhage, necrosis (predominantly of myocytes) and granulocytic exudate in fat or muscle. The most important chronic lesion (28 to 31 days) was fibrosis replacing either tissue. There was a histiolymphocytic exudate with foreign-body giant cells around large lipid vacuoles. Muscle necrosis persisted and there was variable myocyte regeneration. Several specimens showed deep necrosis and abscesses. A grading system was developed to quantitate independently acute and chronic damage in each tissue. Acute lesions were usually less severe and extensive than chronic ones, without obvious dose response. Chronic lesions showed clearly a dose response, which began at 43 degrees C and increased with temperature. The latter appear to be reliable indicators of hyperthermic damage in deep soft tissues.