Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints
Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints
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DOI：
10.1016/j.biopsych.2007.05.030
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发表时间：
2008-03-15
影响因子：
10.6
通讯作者：
de Leon, Mony J.
中科院分区：
文献类型：
--
作者：
Mosconi, Lisa;De Santi, Susan;de Leon, Mony J.
背景：我们检查了认知正常的载脂蛋白 E (ApoE) E4 携带者在主观记忆障碍 (SMC) 中，2-[F-18]氟-2-脱氧-D-葡萄糖 (FDG)-正电子发射断层扫描 (PET) 和脑脊液 (CSF) 标志物上的葡萄糖 (CMRglc) 大脑代谢率是否发生改变。方法：28 名中年正常受试者 (NL)进行了检查，包括 13 名 E4 携带者（E4+；6 名有 SMC [SMC+] 和 7 名无 SMC [SMC-]）和 15 名非携带者（E4-；7 名 SMC+ 和 8 名 SMC-）。受试者接受 FDG-PET 扫描和腰椎穿刺，以测量脑脊液总量 (T-Tau) 和过度磷酸化 tau(213)、(P-Tau)、40 和 42 氨基酸形式的 β-淀粉样蛋白（A beta 40 和 A beta 42）以及 F-2-异前列腺素 (IP)。 结果：与 E4- 相比，E4+ 受试者在 AD 相关中表现出 CMRglc 降低大脑区域和相关较高的 CSF IP、P-Tau、T-Tau 和 P-Tau/A beta 42 水平（p's
Background: We examined whether cerebral metabolic rates for glucose (CMRglc) on 2-[F-18]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) and cerebrospinal fluid (CSF) markers of Alzheimer's disease (AD) are altered in cognitively normal apolipoprotein E (ApoE) E4 carriers with subjective memory complaints (SMC).Methods: Twenty-eight middle-aged normal subjects (NL) were examined, including 13 E4 carriers (E4+; 6 with SMC [SMC+] and 7 without SMC [SMC-]) and 15 noncarriers (E4-; 7 SMC+ and 8 SMC-). Subjects received an FDG-PET scan and a lumbar puncture to measure CSF total (T-Tau) and hyperphosphorylated tau(213), (P-Tau), 40 and 42 amino acid forms of beta-amyloid (A beta 40 and A beta 42), and F-2-isoprostane (IP).Results: As compared with E4-, E4+ subjects showed decreased CMRglc in AD-related brain regions and associated higher CSF IP, P-Tau, T-Tau, and P-Tau/A beta 42 levels (p's