New circulating biomarkers for predicting cardiovascular death in healthy population.
New circulating biomarkers for predicting cardiovascular death in healthy population.
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DOI：
10.1111/jcmm.12652
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发表时间：
2015-10
影响因子：
5.3
通讯作者：
López-Farré AJ
中科院分区：
文献类型：
--
作者：
Melander O;Modrego J;Zamorano-León JJ;Santos-Sancho JM;Lahera V;López-Farré AJ
有兴趣分析新的生物标志物，以确定健康的个人在发展心血管疾病（CVD）事件和死亡的风险。在健康个体中确定新的循环蛋白质生物标志物，其全身水平可能与CVD事件和死亡的未来发展风险相关。该研究在来自马尔默饮食和癌症研究队列的82名个体中进行，其中41名患有CVD，41名没有。分析了与炎症和血栓形成过程相关的血浆蛋白。发生CVD事件的参与者的α1-抗胰蛋白酶同种型3血浆水平显著高于未发生急性心血管事件的参与者，而载脂蛋白J血浆水平则低于未发生急性心血管事件的参与者。在82名参与者中，17人死于CVD原因。与那些没有死于CVD的人相比，患有CVD死亡的参与者血浆中的蛋白质表达显着更高。这些蛋白质包括：纤维蛋白原β-链同种型1和3，纤维蛋白原-γ-链同种型2，维生素D-结合蛋白同种型1、2和3，α1-抗胰蛋白酶同种型3和6，触珠蛋白同种型3、4、5和5，血红素结合蛋白同种型1和2，以及Rho/Rac鸟嘌呤核苷酸交换因子2。此外，在死于心血管原因的参与者中，载脂蛋白J血浆水平较低。血浆蛋白水平与CVD死亡之间的关联独立于年龄、性别、传统危险因素和血浆C反应蛋白水平。与炎症和血栓形成现象相关的几种蛋白质血浆水平和蛋白质同种型与未来CVD死亡的风险独立相关。
There is interest to analyse newer biomarkers to identify healthy individuals at risk to develop cardiovascular disease (CVD) incidents and death. To determine in healthy individuals new circulating protein biomarkers, whose systemic levels may be associated with the risk of future development of CVD incidents and death. The study was performed in 82 individuals from the Malmö Diet and Cancer study cohort, free from CVD of whom 41 developed CVD and 41 did not. Plasma proteins related to inflammation and thrombo-coagulating processes were analysed. α1-antitrypsin isotype 3 plasma levels were significantly higher while apolipoprotein J plasma levels were lower in participants that developed CVD incidents than those that did not develop acute cardiovascular episode. Of 82 participants, 17 died by CVD causes. There were proteins whose expression in plasma was significantly higher in participants suffering CVD death as compared with those that did not die by CVD. These proteins included: fibrinogen β-chain isotypes 1 and 3, fibrinogen-γ-chain isotype 2, vitamin D-binding protein isotypes 1, 2 and 3, α1-antitrypsin isotypes 3 and 6, haptoglobin isotypes 3,4,5 and 5, haemopexin isotypes 1 and 2, and Rho/Rac guanine nucleotide exchange factor 2. Moreover, apolipoprotein J plasma levels were found lower in participants that died by cardiovascular cause. Association between plasma levels of proteins and CVD death was independent of age, gender, conventional risk factors and plasma C-reactive protein levels. Several protein plasma levels and protein isotypes related to inflammation and thrombo-coagulating phenomena were independently associated with the risk of future CVD death.