Effects of High-Dose Dexamethasone on Regulating Interleukin-22 Production and Correcting Th1 and Th22 Polarization in Immune Thrombocytopenia
Effects of High-Dose Dexamethasone on Regulating Interleukin-22 Production and Correcting Th1 and Th22 Polarization in Immune Thrombocytopenia
复制标题
高剂量地塞米松对免疫性血小板减少症中调节白细胞介素 22 产生和纠正 Th1 和 Th22 极化的影响
DOI：
10.1007/s10875-012-9649-4
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发表时间：
2012-06-01
影响因子：
9.1
通讯作者：
Xu, Kai-lin
中科院分区：
文献类型：
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作者：
Cao, Jiang;Chen, Chong;Xu, Kai-lin
研究背景免疫性血小板减少症(ITP)的发病机制与T细胞功能紊乱和T细胞相关细胞因子异常有关。我们以前的一项研究表明，与Th1和Th22细胞相关的IL-22升高在ITP的免疫发病机制中起着重要作用。方法采用酶联免疫吸附试验和流式细胞术检测25例ITP患者治疗前血浆IL-22水平及Th1、Th17、Th22细胞百分率。结果治疗前患者血浆IL-22水平及Th1、Th22细胞百分率与对照组比较差异无统计学意义(P<； )。HD-DXM治疗可减少IL-22的产生，纠正Th1/Th22亚群的失衡。结论HD-DXM治疗前后ITP患者IL-22水平与Th1、Th22细胞水平呈正相关。结论HD-DXM可能通过纠正Th1/Th22极化而调节ITP患者IL-22的产生。
BackgroundT-cell dysregulation and T-cell-related cytokine abnormalities are involved in the pathogenesis of immune thrombocytopenia (ITP). One of our previous studies showed that elevated IL-22 correlated to Th1 and Th22 cells plays an important role in the immunopathogenesis of ITP. In this study, we aimed to investigate the effects of high-dose dexamethasone (HD-DXM) on IL-22 production and on the IL-22-producing T-cell subsets in ITP patients.MethodsIL-22 plasma levels and the percentages of Th1, Th17, and Th22 cells were determined by enzyme-linked immunosorbent assay and flow cytometry in 25 ITP patients receiving DXM 40 mg/day for 4 consecutive days.ResultsPlasma IL-22 concentrations and the percentages of Th1 and Th22 cells were significantly increased in pre-therapy patients relative to controls (P< 0.05), but the percentage of Th17 cells was not. HD-DXM administration reduced IL-22 production and corrected the imbalance between Th1 and Th22 subsets. IL-22 levels were positively correlated with Th1 and Th22 cells in ITP patients before and after HD-DXM treatment.ConclusionThese results suggest that HD-DXM may regulate the production of IL-22 in ITP, possibly by correcting Th1 and Th22 polarization.