Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells
Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells
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DOI：
10.1055/s-2001-11509
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发表时间：
2001-03-01
期刊：
影响因子：
2.7
通讯作者：
Kim, KM
中科院分区：
文献类型：
--
作者：
Ryu, SY;Kou, NY;Kim, KM
从当归（伞形科）根提取物中分离出蛇床素 (1) 和五种相关香豆素，作为活性成分，对培养的肥大细胞的脱颗粒过程具有抑制作用。 Cnidicin (1) 以剂量依赖性方式显着抑制培养的 RBL-2H3 细胞中 β-己糖胺酶的释放（IC50 值，25 μM）以及激活的 RAW264.7 细胞中一氧化氮的产生（IC50 值，7.5 μM）。与此相一致的是，蛇床素抑制RAW264.7细胞中一氧化氮合酶的表达。
Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of beta -hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50 value, 25 muM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50 value, 7.5 muM). In agreement with this, cnidicin inhibited the expression of nitric oxide synthase in RAW264.7 cells.