Diblock-type supramacromolecule via biocomplementary hydrogen bonding.
Diblock-type supramacromolecule via biocomplementary hydrogen bonding.
复制标题
DOI：
10.1021/bm0602280
复制
发表时间：
2006-04
影响因子：
6.2
通讯作者：
Atsushi Noro;Yutaka Nagata;A. Takano;Y. Matsushita
中科院分区：
文献类型：
--
作者：
Atsushi Noro;Yutaka Nagata;A. Takano;Y. Matsushita
通过双嵌段型超大分子通过生物互补氢键控制纳米结构的形成已经实现。两种不同的均聚物，聚（4-三甲基甲硅烷基苯乙烯）和聚（苯乙烯-d8），其末端用互补寡核苷酸修饰，即，胸苷磷酸和脱氧腺苷磷酸通过使用亚磷酰胺法制备并依次混合。用NMR研究了共混溶液中的缔合行为，并通过透射电子显微镜和X-射线散射证实了从该溶液中获得的浇铸体膜显示出纳米相分离的结构。通过加入较小的试剂作为抑制剂，也可以抑制嵌段型超大分子的纳米结构形成。
Control of nanostructure formation by a diblock-type supramacromolecule via biocomplementary hydrogen bonding has been achieved. Two different homopolymers, poly(4-trimethylsilylstyrene) and poly(styrene-d8), that are end-decorated with complementary oligonucleotides, i.e., thymidine phosphates and deoxyadenosine phosphates, were prepared by using the phosphoramidite method and blended successively. Association behavior in a blend solution was examined with NMR, and a cast bulk film obtained from the solution has been confirmed to show a nanophase-separated structure by transmission electron microscopy and X-ray scattering. Suppression of this nanostructure formation of a block-type supramacromolecule was also attained by adding a smaller agent as an inhibitor.