A possible association between maternal dyspepsia and congenital rectal/anal atresia/stenosis in their children: a population-based case-control study
A possible association between maternal dyspepsia and congenital rectal/anal atresia/stenosis in their children: a population-based case-control study
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DOI：
10.1080/00016340903128447
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发表时间：
2009-01-01
影响因子：
4.3
通讯作者：
Czeizel, Andrew E.
中科院分区：
文献类型：
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作者：
Acs, Nandor;Banhidy, Ferenc;Czeizel, Andrew E.
目标.研究常见消化不良（包括胃灼热和胃食管反流病）及其相关药物治疗与其后代先天性畸形（CA）的可能关系。设计以1：2的比例出生的母亲在怀孕早期患有严重的慢性消化不良的情况下，与不同的CA和匹配的对照无缺陷的比较。设置.匈牙利先天性畸形病例控制监测系统。人口CA进行了评估，在信息后代：活产婴儿，死胎，畸形胎儿产前诊断后，然后选择终止妊娠的人口为基础的匈牙利材料。方法.比较了产前分娩日志中记录的产前和医学记录的严重慢性消化不良的妇女，这些妇女后来分娩了具有不同CA的婴儿（病例），并匹配了分娩无任何缺陷新生儿的妇女（对照组）。主要结果指标。不同的CA、胎龄和出生体重、早产率和低出生体重儿。结果在22，843例CA患者中，148例（0.65%）的母亲患有重度慢性消化不良，而38，151例对照中有214例（0.56%）（调整后OR，95%CI = 1.2，0.9-1.4）。与对照组相比，评估的特定CA组显示，仅孤立性直肠/肛门闭锁/狭窄与妊娠早期重度母体消化不良的较高风险相关（调整后OR，95% CI：4.3，1.7-10.5）。结论.妊娠早期重度慢性消化不良和药物治疗与CA的高风险无关，除了可能孤立的直肠/肛门闭锁/狭窄。
Objectives. To study the possible association of common dyspepsia including heartburn and gastro-esophageal reflux disease and its related drug treatments in pregnant women with congenital anomalies (CAs) in their offspring. Design. Comparison of cases affected with different CAs and matched controls without defects in a ratio of 1: 2 born to mothers affected with severe chronic dyspepsia in early pregnancy. Setting. Hungarian Case Control Surveillance System of Congenital Abnormalities. Population. CAs were evaluated in informative offspring: live-born infants, stillborn fetuses, and malformed fetuses after prenatal diagnosis followed by elective termination of pregnancy in the population-based Hungarian material. Methods. Prospectively and medically recorded severe chronic dyspepsia recorded in the prenatal maternity logbook was compared among women who later delivered babies with different CAs (cases) and matched women who delivered newborns without any defect (controls). Main outcome measures. Different CAs, gestational age and birthweight, rates of preterm birth, and low birthweight newborns. Results. Of 22,843 cases with CAs, 148 (0.65%) had mothers with severe chronic dyspepsia, compared to 214 (0.56%) of 38,151 controls (adjusted OR with 95% CI = 1.2, 0.9-1.4). Specific groups of CAs assessed vs. controls showed that only isolated rectal/anal atresia/stenosis was associated with a higher risk of severe maternal dyspepsia in early pregnancy (adjusted OR with 95% CI: 4.3, 1.7-10.5). Conclusions. Severe chronic dyspepsia in early pregnancy and drug treatment for this was not associated with a higher risk of CAs, except possibly isolated rectal/anal atresia/stenosis.