Effect of DISC1 on the P300 waveform in psychosis.
Effect of DISC1 on the P300 waveform in psychosis.
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DISC1 对精神病中 P300 波形的影响。
DOI：
10.1093/schbul/sbr101
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发表时间：
2013
影响因子：
6.6
通讯作者：
Murray,R
中科院分区：
文献类型：
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作者：
Shaikh,Madiha;Hall,Mei-Hua;Schulze,Katja;Dutt,Anirban;Li,Kuang;Williams,Ian;Walshe,Muriel;Constante,Miguel;Broome,Matthew;Picchioni,Marco;Toulopoulou,Timothea;Collier,David;Stahl,Daniel;Rijsdijk,Fruhling;Powell,John;Murray,R
引言：神经生理学测量中的异常P300振幅和潜伏期构成了精神病的内表型。Disrupted-in-Schizophrenia-1（DISC 1）是精神分裂症的易感基因，与精神分裂症的P300缺陷有关。方法：采用线性回归和单倍型分析方法，对149例精神分裂症或精神病性双相情感障碍患者、130例正常对照和208例健康对照的DISC 1基因多态性进行了研究。结果：DISC 1基因多态性与P300内表型有关，与P300内表型有关。P300波幅和潜伏期与DISC 1基因多态性/单倍型显著相关，单核苷酸多态性（SNP）A等位基因纯合子P300波幅和潜伏期与DISC 1基因单倍型显著相关，与G等位基因纯合子组（P= .009）和杂合子组（P= .018）相比，rs 821597显示出显著降低的P300振幅。单倍型分析显示，DISC 1单倍型（rs3738401）与乳腺癌的发生有显著相关性|rs6675281| rs821597| rs821616| rs967244| rs 980989）和P300潜伏期。单倍型GCGTCG和ACGTTT与较短的lavele.Discussion：P300波形似乎是调制的变化，在个别SNPs和单倍型的DISC 1。由于DISC 1参与神经发育，因此有一种假设认为神经连接的中断会损害认知过程，如本样本中观察到的P300缺陷所示。
Introduction:Abnormalities in the neurophysiological measures P300 amplitude and latency constitute endophenotypes for psychosis. Disrupted-in-Schizophrenia-1 (DISC1) has been proposed as a promising susceptibility gene for schizophrenia, and a previous study has suggested that it is associated with P300 deficits in schizophrenia.Methods:We examined the role of variation inDISC1polymorphisms on the P300 endophenotype in a large sample of patients with schizophrenia or psychotic bipolar disorder (n= 149), their unaffected relatives (n= 130), and unrelated healthy controls (n= 208) using linear regression and haplotype analysis.Results:Significant associations between P300 amplitude and latency andDISC1polymorphisms/haplotypes were found. Those homozygous for the A allele of single-nucleotide polymorphism (SNP) rs821597 displayed significantly reduced P300 amplitudes in comparison with homozygous for the G allele (P= .009) and the heterozygous group (P= .018). Haplotype analysis showed a significant association forDISC1haplotypes (rs3738401|rs6675281|rs821597|rs821616|rs967244|rs980989) and P300 latency. Haplotype GCGTCG and ACGTTT were associated with shorter latencies.Discussion:The P300 waveform appears to be modulated by variation in individual SNPs and haplotypes ofDISC1. BecauseDISC1is involved in neurodevelopment, one hypothesis is that disruption in neural connectivity impairs cognitive processes illustrated by P300 deficits observed in this sample.