Oscillations and waves of cyclic AMP in Dicyostelium:: A prototype for spatio-temporal organization and pulsatile intercellular communication
Oscillations and waves of cyclic AMP in Dicyostelium:: A prototype for spatio-temporal organization and pulsatile intercellular communication
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DOI：
10.1007/s11538-006-9090-z
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发表时间：
2006-07-01
影响因子：
3.5
通讯作者：
Goldbeter, Albert
中科院分区：
文献类型：
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作者：
Goldbeter, Albert
变形虫网骨藻。在饥饿后，盘状体以波浪状的方式聚集，以响应由作为聚集中心的细胞分泌的周期性脉冲的环AMP（cAMP）。除了自主振荡之外，控制聚集的cAMP信号系统还能够产生兴奋行为，其中包括细胞外cAMP阈上脉冲的瞬时放大。自1970年Keller和Segel提出黏菌聚集的第一个理论模型以来，许多理论研究已经解决了环腺苷酸信号转导在Dictilosteletin中的机制和功能的各个方面。本文简要概述了这些发展，以及作者的合作与李西格尔在建模cAMP继电器和振荡的动力学的一些回忆。依次考虑的是网骨藻中cAMP信号传导的模型，饥饿后cAMP信号传导系统的发育路径，cAMP信号的频率编码，以及cAMP同心波或螺旋波的起源。
The amoebae Dictyostelium. discoideum aggregate after starvation in a wavelike manner in response to periodic pulses of cyclic AMP (cAMP) secreted by cells which behave as aggregation centers. In addition to autonomous oscillations, the cAMP signaling system that controls aggregation is also capable of excitable behavior, which consists in the transient amplification of suprathreshold pulses of extracellular cAMP. Since the first theoretical model for slime mold aggregation proposed by Keller and Segel in 1970, many theoretical studies have addressed various aspects of the mechanism and function of cAMP signaling in Dictilostelium. This paper presents a brief overview of these developments as well as some reminiscences of the author's collaboration with Lee Segel in modeling the dynamics of cAMP relay and oscillations. Considered in turn are models for cAMP signaling in Dictyostelium, the developmental path followed by the cAMP signaling system after starvation, the frequency encoding of cAMP signals, and the origin of concentric or spiral waves of cAMP.