GENETIC-CONTROL OF ACQUIRED-RESISTANCE TO HAEMONCHOSIS IN MERINO LAMBS
GENETIC-CONTROL OF ACQUIRED-RESISTANCE TO HAEMONCHOSIS IN MERINO LAMBS
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DOI：
10.1111/j.1365-3024.1991.tb00557.x
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发表时间：
1991-11-01
影响因子：
2.2
通讯作者：
GILL, HS
中科院分区：
文献类型：
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作者：
GILL, HS
遗传抗性和随机繁殖羔羊对H.研究了扭体。 抗性羔羊有较高的粪便虫卵计数和总蠕虫负担比随机繁殖的羔羊以下的主要感染。 由于两组之间的血清和抗体水平、粘膜肥大细胞、循环和组织嗜酸性粒细胞无显著差异，因此推断无论潜在机制如何，其均为先天性特征。 与初次感染相比，抗性羔羊的粪便虫卵计数和蠕虫负担显着低于随机繁殖的羔羊二次感染。 抵抗羔羊也表现出显着更高的抗体水平，粘膜肥大细胞增生和粘膜嗜酸性粒细胞增多症，在应对挑战感染比随机繁殖的羔羊。 此外，肥大细胞增生和抗血矛线虫抗体水平与宿主的抵抗状态呈正相关。 这些结果表明绵羊对H.捻转是由获得性免疫反应的表达引起的，抗寄生虫抗体和肥大细胞衍生的介质可能在绵羊对血吸虫病的遗传决定性抗性中起重要作用。
Parasitological and immunological responses of genetically resistant and random-bred lambs to primary and secondary infection with H. contortus were studied. Resistant lambs had higher faecal egg counts and total worm burdens than the random-bred lambs following the primary infection. As there were no significant differences in serum and antibody levels, mucosal mast cells, circulating and tissue eosinophils between the two groups, it is inferred that what ever the underlying mechanism it was an innate characteristic. In contrast to primary infection, resistant lambs had significantly lower faecal egg counts and worm burdens than the random-bred lambs on secondary infection. Resistant lambs also exhibited significantly higher antibody levels, mucosal mast cell hyperplasia and mucosal eosinophilia in response to a challenge infection than the random-bred lambs. Furthermore, levels of mast cell hyperplasia and anti-Haemonchus antibodies correlated positively with the resistance status of the host. Taken together these results suggest that the genetic resistance of sheep to H. contortus results from the expression of an acquired immune response, and that anti-parasite antibodies and mast cell-derived mediators may play an important role in genetically determined resistance of sheep to haemonchosis.