Obstructive sleep apnea and hypertension.
Obstructive sleep apnea and hypertension.
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DOI：
10.1007/s11886-005-0061-z
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发表时间：
2005-11-01
影响因子：
3.7
通讯作者：
Somers, Virend K
中科院分区：
文献类型：
--
作者：
Narkiewicz, Krzysztof;Wolf, Jacek;Somers, Virend K
越来越多的证据表明阻塞性睡眠呼吸暂停（OSA）和高血压之间存在因果关系。未经治疗的OSA可能通过几种机制对心血管功能和结构产生直接和有害的影响，包括交感神经激活、氧化应激、炎症和内皮功能障碍。OSA可能导致或增加大部分高血压患者人群的血压水平升高。在肥胖的高血压患者的鉴别诊断中考虑OSA是很重要的。对于那些对降压药物联合治疗反应较差的高血压患者，应特别考虑OSA。
There is growing evidence of a causal relationship between obstructive sleep apnea (OSA) and hypertension. Untreated OSA may have direct and deleterious effects on cardiovascular function and structure through several mechanisms, including sympathetic activation, oxidative stress, inflammation, and endothelial dysfunction. OSA may contribute to or augment elevated blood pressure levels in a large proportion of the hypertensive patient population. It is important to consider OSA in the differential diagnosis of hypertensive patients who are obese. OSA should be especially considered in those hypertensive patients who respond poorly to combination therapy with antihypertensive medications.