Sensory gating revisited: Relation between brain oscillations and auditory evoked potentials in schizophrenia
Sensory gating revisited: Relation between brain oscillations and auditory evoked potentials in schizophrenia
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DOI：
10.1016/j.schres.2007.10.034
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发表时间：
2008-02-01
影响因子：
4.5
通讯作者：
Klosterkoetter, Joachim
中科院分区：
文献类型：
--
作者：
Brockhaus-Dumke, Anke;Mueller, Ralf;Klosterkoetter, Joachim
听觉信息处理障碍在精神分裂症中反复出现。为了更好地理解听觉加工习惯化的神经生理学基础及其在精神分裂症中的障碍，我们使用了三种不同的方法来分析听觉诱发反应，即锁相分析（PL）、单次试验振幅和平均事件相关电位（P50和N100）。考虑到大脑振荡反映了信息处理的神经元关联，我们假设声压和振幅反映了比平均ERP反应更重要的听觉处理部分。对32例精神分裂症患者和32例对照者采用听觉配对点击模式连续记录脑电图。较低频段（α和θ）的PL在患者中显著降低，而较高频段（α和β）的PL无显著差异。Alpha和theta声压和振幅在第一次点击后明显增加，在第二次点击后略有增加。这种习惯化在对照组中更为突出，而在精神分裂症患者中，对两种点击的反应仅略有不同。精神分裂症患者的N100抑制显著降低，而P50没有组间差异。这与Gamma主要用于预测P50反应和theta主要用于预测N100反应的发现相一致。我们的数据表明，在单个试验中分析相位和振幅比分析平均ERP反应更能反映精神分裂症患者和对照组之间的听觉信息加工差异。(C) 2007 Elsevier B.V.版权所有
Disturbances of auditory information processing have repeatedly been shown in schizophrenia. To contribute to a better understanding of the neurophysiological underpinnings of habituation in auditory processing and its disturbance in schizophrenia we used three different approaches to analyze auditory evoked responses, namely phase-locking (PL) analyses, single trial amplitudes, and averaged event-related potentials (P50 and N100). Given that brain oscillations reflect the neuronal correlates of information processing we hypothesized that PL and amplitudes reflect even more essential parts of auditory processing than the averaged ERP responses. In 32 schizophrenia patients and 32 matched controls EEG was continuously recorded using an auditory paired click paradigm. PL of the lower frequency bands (alpha and theta) was significantly reduced in patients whereas no significant differences were present in higher frequencies (gamma and beta). Alpha and theta PL and amplitudes showed a marked increase after the first click and to a minor degree after the second one. This habituation was more prominent in controls whereas in schizophrenia patients the response to both clicks differed only slightly. N100 suppression was significantly reduced in schizophrenia patients whereas no group differences were present with respect to the P50. This corresponded to the finding that Gamma mostly contributed to the prediction of the P50 response and theta mostly to the N100 response.Our data showed that analyzing phase and amplitude in single trials provides more information on auditory information processing and reflects differences between schizophrenia patients and controls better than analyzing the averaged ERP responses. (C) 2007 Elsevier B.V. All rights reserved.