Current perspectives on Gleason grading of prostate cancer.
Current perspectives on Gleason grading of prostate cancer.
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DOI：
10.1007/s11934-011-0181-5
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发表时间：
2011-06-01
影响因子：
2.6
通讯作者：
Lucia, M Scott
中科院分区：
文献类型：
--
作者：
Iczkowski, Kenneth A;Lucia, M Scott
1966年推出的前列腺癌5级Gleason分级系统已被证明是前列腺癌结局的主要独立预测因素之一。本综述讨论了观察者间Gleason分级的一致性;从活检到膀胱切除标本频繁升级的分级差异的持续性; 2005年国际泌尿外科病理学家学会对Gleason分级的修改;这种修改后的分级对分级迁移和结局预测的影响;以及癌症形态学的分子相关性。强调了最近几年的数据。
The 5-tier Gleason grading system for prostate cancer, introduced in 1966, has been proven to be one of the main independent predictors of prostate cancer outcome. This review addresses interobserver concordance in Gleason grading; the persistence of grading discrepancies with frequent upgrading from the biopsy to the prostatectomy specimen; the 2005 International Society of Urologic Pathologists' modifications to Gleason grading; the impact of this modified grading on grade migration and outcome prediction; and molecular correlates of cancer morphology. Data from the most recent years are emphasized.