Identification of a Key Prenyltransferase Involved in Biosynthesis of the Most Abundant Fungal Meroterpenoids Derived from 3,5-Dimethylorsellinic Acid.
Identification of a Key Prenyltransferase Involved in Biosynthesis of the Most Abundant Fungal Meroterpenoids Derived from 3,5-Dimethylorsellinic Acid.
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DOI：
10.1002/cbic.201200124
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发表时间：
2012-05-29
期刊：
影响因子：
3.2
通讯作者：
Kushiro, Tetsuo
中科院分区：
文献类型：
--
作者：
Itoh, Takayuki;Tokunaga, Kinya;Kushiro, Tetsuo
破坏芳香性：一种参与真菌类化合物生物合成的新型异戊烯基转移酶(Trt2)被证明能催化一个不寻常的芳香加成反应到一个完全取代的芳环上。异戊烯基化产物是真菌中含量最丰富的硫代萜类化合物生物合成的关键中间体。
Destroying aromaticity: A novel prenyltransferase (Trt2) involved in fungal meroterpenoid biosynthesis was shown to catalyze an unusual aromatic addition reaction onto a fully substituted aromatic ring. The prenylated product serves as a key intermediate in the biosynthesis of the most abundant series of meroterpenoids in fungi.