Moving and positioning the endolysosomal system.
Moving and positioning the endolysosomal system.
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DOI:
10.1016/j.ceb.2017.01.008
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发表时间:
2017-08
影响因子:
7.5
通讯作者:
Neefjes J
中科院分区:
文献类型:
--
作者:
Bonifacino JS;Neefjes J
The endolysosomal system is extremely dynamic, yet highly organized. The spatiotemporal distribution of endolysosomal organelles depends on transport driven by microtubule motors such as kinesins and dynein, and by actin-based myosin motors. It has recently become appreciated that interactions with motors are controlled by contacts with other organelles, particularly the endoplasmic reticulum (ER). The ER also controls the concentration of endolysosomal organelles in the perinuclear area, as well as their fission and fusion, through a complex system of tethering proteins. Dynamic interactions go both ways, as contacts with endosomes can influence the movement of the ER and peroxisomes. The dynamics of endolysosomal organelles should thus no longer be studied in isolation, but in the context of the whole endomembrane system.
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DOI:
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2011-07
期刊:
Traffic (Copenhagen, Denmark)
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