Comparison of iron oxide nanoparticle and microwave hyperthermia alone or combined with cisplatinum in murine breast tumors.
Comparison of iron oxide nanoparticle and microwave hyperthermia alone or combined with cisplatinum in murine breast tumors.
复制标题
氧化铁纳米颗粒和微波热疗单独或联合顺铂治疗小鼠乳腺肿瘤的比较。
DOI：
10.1117/12.876535
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Hoopes,PJack
中科院分区：
文献类型：
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作者：
Petryk,AliciaA;Stigliano,RobertV;Giustini,AndrewJ;Gottesman,RachelE;Trembly,BStuart;Kaufman,PeterA;Hoopes,PJack
手术、放疗和化疗是目前最常用的癌症治疗方法。热疗已被证明与放射和化学疗法癌症治疗有效。以前的热疗技术所面临的主要障碍是无法以精确的方式将热量传递到肿瘤。通过氧化铁磁性纳米颗粒（mNP）向肿瘤（从单个细胞内）递送细胞毒性热疗的能力是一种有前途的新技术，其能够极大地提高热疗作为个体方式以及作为与其他方式组合的辅助治疗的治疗率。虽然参数尚未最终确定，但初步数据表明mNP热疗可以实现比传统水浴热疗方法更大的细胞毒性（体外）。此时，我们的理论是，细胞内纳米颗粒加热比细胞外加热技术更有效地实现组合效应。1然而，理解mNP缔合和摄取的重要性对于理解加热方式的潜在新奇至关重要。我们的初步数据表明，mNP加热技术，它没有提供时间的颗粒吸收的细胞，导致类似的疗效微波热疗。mNP热疗/顺铂结果显示，在相当的剂量下，肿瘤生长延迟大于单独的任何一种方式。
Surgery, radiation and chemotherapy are currently the most commonly used cancer therapies. Hyperthermia has been shown to work effectively with radiation and chemotherapy cancer treatments. The major obstacle faced by previous hyperthermia techniques has been the inability to deliver heat to the tumor in a precise manner. The ability to deliver cytotoxic hyperthermia to tumors (from within individual cells) via iron oxide magnetic nanoparticles (mNP) is a promising new technology that has the ability to greatly improve the therapeutic ratio of hyperthermia as an individual modality and as an adjuvant therapy in combination with other modalities. Although the parameters have yet to be conclusively defined, preliminary data suggests mNP hyperthermia can achieve greater cytotoxicity (in vitro) than conventional water bath hyperthermia methods. At this time, our theory is that intracellular nanoparticle heating is more effective in achieving the combined effect than extracellular heating techniques.1 However, understanding the importance of mNP association and uptake is critical in understanding the potential novelty of the heating modality. Our preliminary data suggests that the mNP heating technique, which did not provide time for particle uptake by the cells, resulted in similar efficacy to microwave hyperthermia. mNP hyperthermia/cisplatinum results have shown a tumor growth delay greater than either modality alone at comparable doses.