Metabolic syndrome and insulin resistance are associated with abnormal left ventricular diastolic function and structure independent of blood pressure and fasting plasma glucose level
Metabolic syndrome and insulin resistance are associated with abnormal left ventricular diastolic function and structure independent of blood pressure and fasting plasma glucose level
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DOI：
10.1016/j.ijcard.2011.02.039
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发表时间：
2012-08-23
影响因子：
3.5
通讯作者：
Lee, Moon-Kyu
中科院分区：
文献类型：
--
作者：
Hwang, You-Cheol;Jee, Jae Hwan;Lee, Moon-Kyu
背景：在多种心脏疾病中经常发现左心室结构和舒张期功能异常，胰岛素抵抗被认为与左室舒张功能不全(LVDD)有关。这项研究的目的是确定LVDD或LV结构与代谢综合征(METS)或胰岛素抵抗的相关性，以及这种相关性是否独立于年龄、血压和血糖水平。方法：共有1599名(男性1161名，女性398名)，年龄25-83岁，在两个机构接受体检。结果：即使在调整了年龄、性别、血压和空腹血糖水平后，反映心脏结构和左室舒张功能的参数水平在反映心脏结构和左室舒张功能的指标上仍有显著差异(P<0.05)。
Background: Abnormal left ventricular (LV) structure and diastolic function are frequently detected in a variety of heart diseases, and insulin resistance has been suggested to be associated with LV diastolic dysfunction (LVDD). The aims of this study were to determine the association between LVDD or LV structure and metabolic syndrome (MetS) or insulin resistance, and whether or not the associations are independent of age, blood pressure, and plasma glucose level.Methods: A total of 1599 subjects (1161 men and 398 women), 25-83 years of age, who underwent medical health check-ups at two institutions, were enrolled. LV diastolic function and structure were assessed by echocardiographic evaluation, including tissue Doppler imaging (TDI).Results: The subjects with MetS had significant differences in the level of parameters reflecting cardiac structure and LV diastolic function compared to those without MetS, even after adjustment for age, gender, blood pressure, and fasting plasma glucose level (P