Regulation of intracellular membrane trafficking and cell dynamics by syntaxin-6.
Regulation of intracellular membrane trafficking and cell dynamics by syntaxin-6.
复制标题
DOI：
10.1042/bsr20120006
复制
发表时间：
2012-08
影响因子：
4
通讯作者：
Choudhury A
中科院分区：
文献类型：
--
作者：
Jung JJ;Inamdar SM;Tiwari A;Choudhury A
沿着内吞和分泌运输途径的细胞内膜运输在包括发育和病理过程在内的多种细胞功能中发挥着关键作用。简而言之，运往不同位置的蛋白质和脂质被共同组装成囊泡，并通过囊泡融合递送至其目标位点。这些事件需要 SNARE（可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体）蛋白，在此期间 v-SNARE（囊泡 SNARE）与 t-SNARE（目标 SNARE）相互作用，以允许货物从供体囊泡转移到目标膜。最近，t-SNARE 家族成员 Syntaxin-6 已被证明在蛋白质运输中发挥着重要作用，而蛋白质是多种细胞动态过程的关键。在本文中，我们简要讨论了 SNARE 在各种哺乳动物细胞类型中的具体作用，并全面回顾了高尔基体和内体定位的 t-SNARE、syntaxin-6 在生理和病理条件下膜运输中的各种作用。
Intracellular membrane trafficking along endocytic and secretory transport pathways plays a critical role in diverse cellular functions including both developmental and pathological processes. Briefly, proteins and lipids destined for transport to distinct locations are collectively assembled into vesicles and delivered to their target site by vesicular fusion. SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein receptor) proteins are required for these events, during which v-SNAREs (vesicle SNAREs) interact with t-SNAREs (target SNAREs) to allow transfer of cargo from donor vesicle to target membrane. Recently, the t-SNARE family member, syntaxin-6, has been shown to play an important role in the transport of proteins that are key to diverse cellular dynamic processes. In this paper, we briefly discuss the specific role of SNAREs in various mammalian cell types and comprehensively review the various roles of the Golgi- and endosome-localized t-SNARE, syntaxin-6, in membrane trafficking during physiological as well as pathological conditions.