Success of a suicidal defense strategy against infection in a structured habitat.
Success of a suicidal defense strategy against infection in a structured habitat.
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DOI：
10.1038/srep00238
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发表时间：
2012
影响因子：
4.6
通讯作者：
Kobayashi, Ichizo
中科院分区：
文献类型：
--
作者：
Fukuyo, Masaki;Sasaki, Akira;Kobayashi, Ichizo
当宿主-病原体共生似乎对病原体更有利时，病原体感染常常导致毒力表达和宿主死亡。以前提出的解释都集中在病原体方面。在这项工作中，我们测试了一个假设集中在主机策略。如果宿主种群的一个成员在感染后立即死亡，使病原体繁殖中止，它可以保护宿主种群免受二次感染。我们通过开发一个实验感染系统来测试这种“自杀性感染防御”（SDAI）假设，该系统涉及大量细菌作为宿主，其病毒作为病原体，这与建模和模拟有关。我们的实验和模拟表明，SDAI策略的人口是成功的，在空间结构的存在，但在它的情况下失败。感染导致除了对病原体具有抗性的宿主突变体之外，不诱导宿主自杀的病原体突变体的出现。
Pathogen infection often leads to the expression of virulence and host death when the host-pathogen symbiosis seems more beneficial for the pathogen. Previously proposed explanations have focused on the pathogen's side. In this work, we tested a hypothesis focused on the host strategy. If a member of a host population dies immediately upon infection aborting pathogen reproduction, it can protect the host population from secondary infections. We tested this "Suicidal Defense Against Infection" (SDAI) hypothesis by developing an experimental infection system that involves a huge number of bacteria as hosts and their virus as pathogen, which is linked to modeling and simulation. Our experiments and simulations demonstrate that a population with SDAI strategy is successful in the presence of spatial structure but fails in its absence. The infection results in emergence of pathogen mutants not inducing the host suicide in addition to host mutants resistant to the pathogen.
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影响因子：
12.3
作者：
Fukuda, Eri;Kaminska, Katarzyna H.;Bujnicki, Janusz M.;Kobayashi, Ichizo
通讯作者：
Kobayashi, Ichizo
DOI：
10.1073/pnas.78.10.6324
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CHAO, L;LEVIN, BR
通讯作者：
LEVIN, BR
影响因子：
2
作者：
Haraguchi, Y;Sasaki, A
通讯作者：
Sasaki, A
影响因子：
2.9
作者：
Ross-Gillespie, Adin;Gardner, Andy;Griffin, Ashleigh S.
通讯作者：
Griffin, Ashleigh S.
影响因子：
2.1
作者：
Ohashi, Y;Ohshima, H;Itaya, M
通讯作者：
Itaya, M