Investigating paternal preconception risk factors for adverse pregnancy outcomes in a population of internet users.
Investigating paternal preconception risk factors for adverse pregnancy outcomes in a population of internet users.
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DOI：
10.1186/s12978-016-0156-6
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发表时间：
2016-04-14
影响因子：
3.4
通讯作者：
Tozzi AE
中科院分区：
文献类型：
--
作者：
Agricola E;Gesualdo F;Carloni E;D'Ambrosio A;Russo L;Campagna I;Pandolfi E;Tozzi AE
父亲的先入为主的风险因素，如吸烟、暴露于环境物质、药物使用、超重和高龄与后代畸形和出生缺陷的发生有关。尽管如此，男性人群中不良妊娠结局的风险因素的流行率几乎没有调查，也没有针对未来父亲的怀孕前干预措施的报告。我们进行了一项基于网络的调查，以衡量意大利互联网用户群体中不良妊娠结局的父亲先孕风险因素的流行率。在为期四周的时间里，准爸爸或准爸爸通过两个主要的意大利网站注册，这些网站致力于未孕、怀孕、儿童和家庭护理。参与者填写了一份关于不良妊娠结局的怀孕前风险因素的网络问卷。用Logistic回归分析探讨父亲先孕危险因素的预测因素。我们招募了131名准爸爸和205名准爸爸。超过一半的参与者在怀孕前使用药物，35%的人是吸烟者，8%的人肥胖。近20%的参与者声称接触了环境物质，其中包括杀虫剂/除草剂/专业涂料在内的这一组最普遍。超过一半的研究样本包括35岁以上的男性。多因素分析显示，大学学历者吸烟和接触环境毒物的频率较低(OR = 为0.5 2；95%CI为0.32~0.84；OR = 为0.52；95%CI为0.2 9~0.93)。父亲肥胖和未孕期间的用药与任何自变量都没有关联。在计划先孕干预措施时，男性人群中先孕危险因素的流行不应被忽视，这证实了先孕健康必须以夫妇为重点，而不是仅针对女性。本文的在线版本(doi：10.1186/s12978-0160156-6)包含补充材料，授权用户可以使用。
Paternal preconception risk factors such as smoking, exposure to environmental substances, medication use, overweight and advanced age correlate with the occurrence of malformations and birth defects in the offspring. Nonetheless, the prevalence of risk factors for adverse pregnancy outcomes in the male population has been scarcely investigated and no report on preconception interventions targeting prospective fathers is available. We conducted a web-based survey to measure the prevalence of paternal preconception risk factors for adverse pregnancy outcomes in an Italian population of Internet users. Prospective or expectant fathers were enrolled during a four-week period through two of the main Italian web-sites dedicated to preconception, pregnancy, childhood and family care. Participants filled in a web questionnaire regarding preconception risk factors for adverse pregnancy outcomes. Logistic regression analysis was used to explore the predictors of paternal preconception risk factors. We enrolled 131 prospective and 205 expectant fathers. More than half of the total participants used medications during the preconception period, 35 % were smokers and 8 % were obese. Exposure to environmental substances was declared by almost 20 % of the participants, with the group including pesticides/herbicides/professional paints being the most prevalent. More than a half of the study sample included men aged over 35 years. According to the multivariate analysis, smoking and exposure to environmental toxics were less frequent among individuals with a university degree (respectively: OR = 0.52; 95 % CI 0.32–0.84; OR = 0.52; 95 % CI 0.29–0.93). Paternal obesity and medication use in the preconception period were not associated with any of the independent variables. The prevalence of preconception risk factors among male population should not be neglected when planning preconception interventions, confirming that preconception health must be focused on the couple, rather than on women only. The online version of this article (doi:10.1186/s12978-016-0156-6) contains supplementary material, which is available to authorized users.