Brain network analysis reveals affected connectome structure in bipolar I disorder.
Brain network analysis reveals affected connectome structure in bipolar I disorder.
复制标题
DOI：
10.1002/hbm.23017
复制
发表时间：
2016-01
影响因子：
4.8
通讯作者：
Kahn RS
中科院分区：
文献类型：
--
作者：
Collin G;van den Heuvel MP;Abramovic L;Vreeker A;de Reus MA;van Haren NE;Boks MP;Ophoff RA;Kahn RS
健康的大脑功能来自于受大脑解剖连接网络（即连接体）约束的协调神经活动，这一概念表明连接体布线模式的改变可能是大脑疾病的基础。对精神分裂症的研究证实了这一假设，表明连接体结构发生了改变，包括通信效率降低、中枢脑枢纽中断和受影响的“富人俱乐部”组织。目前尚不清楚双相情感障碍是否存在类似的缺陷。这项研究检查了216名双相I型障碍患者与144名健康对照者的结构连接体拓扑学，特别关注中心区域（即，脑中枢）和连接（即，丰富的俱乐部连接，大脑半球间的连接）。我们发现，双相I型障碍患者表现出整体效率降低（-4.4%，p = 0.002），这种缺陷与半球间连接强度降低（-13.0%，p = 0.001）有关（r = 0.56，p <0.001）。发现双相情感障碍患者在一般脑中枢连接或跨越脑中枢的连接（即，“富人俱乐部”联系）尤其如此（所有p > 0.1）。这些发现突出了双相I型障碍中异常脑网络结构的作用，其与半球间连接中断相关的全球效率降低，而中央“富人俱乐部”系统似乎没有受到特别影响。
The notion of healthy brain function emerging from coordinated neural activity constrained by the brain’s network of anatomical connections – i.e. the connectome – suggests that alterations in the connectome’s wiring pattern may underlie brain disorders. Corroborating this hypothesis, studies in schizophrenia are indicative of altered connectome architecture including reduced communication efficiency, disruptions of central brain hubs and affected ‘rich club’ organization. Whether similar deficits are present in bipolar disorder is currently unknown. This study examines structural connectome topology in 216 bipolar I disorder patients as compared to 144 healthy controls, focusing in particular on central regions (i.e., brain hubs) and connections (i.e., rich club connections, inter-hemispheric connections) of the brain’s network. We find that bipolar I disorder patients exhibit reduced global efficiency (−4.4%, p = 0.002) and that this deficit relates (r = 0.56, p < 0.001) to reduced connectivity strength of inter-hemispheric connections (−13.0%, p = 0.001). Bipolar disorder patients were found not to show predominant alterations in the strength of brain hub connections in general, or of connections spanning brain hubs (i.e., ‘rich club’ connections) in particular (all p > 0.1). These findings highlight a role for aberrant brain network architecture in bipolar I disorder with reduced global efficiency related to disruptions in inter-hemispheric connectivity, while the central ‘rich club’ system appears not to be particularly affected.
登录
查看更多内容
影响因子：
5.4
作者：
Goes, Fernando S.;Sadler, Bradley;Potash, James B.
通讯作者：
Potash, James B.
DOI：
10.1093/brain/awu132
发表时间：
2014-08
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Crossley NA;Mechelli A;Scott J;Carletti F;Fox PT;McGuire P;Bullmore ET
通讯作者：
Bullmore ET
影响因子：
5.7
作者：
Griffa, Alessandra;Baumann, Philipp S.;Hagmann, Patric
通讯作者：
Hagmann, Patric
影响因子：
10.6
作者：
Altman, EG;Hedeker, D;Davis, JM
通讯作者：
Davis, JM
影响因子：
6.6
作者：
Collin G;Kahn RS;de Reus MA;Cahn W;van den Heuvel MP
通讯作者：
van den Heuvel MP