Spatial tuning of acoustofluidic pressure nodes by altering net sonic velocity enables high-throughput, efficient cell sorting.

Spatial tuning of acoustofluidic pressure nodes by altering net sonic velocity enables high-throughput, efficient cell sorting.
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通过改变净声速来空间调整声流体压力节点可实现高通量、高效的细胞分选。

DOI:
10.1039/c4lc01342e
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发表时间:
2015
期刊:
影响因子:
6.1
通讯作者:
Weinberger,LeorS
Weinberger,LeorS
中科院分区:
工程技术1区
文献类型:
--
作者:
Jung,Seung-Yong;Notton,Timothy;Fong,Erika;Shusteff,Maxim;Weinberger,LeorS

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使用声流体的颗粒分选具有巨大的潜力,但广泛采用受到复杂设备设计和低通量的限制。在这里,我们报告了通过改变净声速来重新定位简单的双通道装置中的声压节点来高通量分离颗粒和T淋巴细胞(600 μL min−1)。该方法可推广到其他微流体平台,用于快速,高通量分析。
Particle sorting using acoustofluidics has enormous potential but widespread adoption has been limited by complex device designs and low throughput. Here, we report high-throughput separation of particles and T lymphocytes (600 μL min−1) by altering the net sonic velocity to reposition acoustic pressure nodes in a simple two-channel device. The approach is generalizable to other microfluidic platforms for rapid, high-throughput analysis.