Clinical significance of T cell metabolic reprogramming in cancer.
Clinical significance of T cell metabolic reprogramming in cancer.
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DOI：
10.1186/s40169-016-0110-9
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发表时间：
2016-12
影响因子：
10.6
通讯作者：
Boussiotis VA
中科院分区：
文献类型：
--
作者：
Herbel C;Patsoukis N;Bardhan K;Seth P;Weaver JD;Boussiotis VA
正常细胞向癌症的转化伴随着它们新陈代谢的变化。在这种转化过程中，细胞代谢经历了从氧化磷酸化到有氧糖酵解的转变，也被称为Warburg效应，这是癌细胞代谢的标志。在癌细胞中，糖酵解与TCA循环和其他代谢途径并行，以增强生物合成过程，从而支持增殖和生长。在T细胞活化过程中也观察到类似的代谢特征，但与癌症不同的是，T细胞的代谢转变是生理过程的一部分。目前，人们对了解代谢重编程与T细胞分化之间的因果关系非常感兴趣。随着近年来癌症免疫治疗的成功，免疫系统与癌症之间的相互作用已经成为临床和基础研究的前沿。其中一个关键目标是描述癌症的代谢改变如何影响代谢调节功能和肿瘤驻留T细胞的分化，以及免疫治疗如何改变这种影响。在这里，我们回顾了癌症独特的代谢特征，癌症代谢对抗原接触过程中T细胞代谢重编程的影响，以及利用癌症和T细胞代谢进行癌症治疗的转化前景。
Conversion of normal cells to cancer is accompanied with changes in their metabolism. During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to aerobic glycolysis, also known as Warburg effect, which is a hallmark for cancer cell metabolism. In cancer cells, glycolysis functions in parallel with the TCA cycle and other metabolic pathways to enhance biosynthetic processes and thus support proliferation and growth. Similar metabolic features are observed in T cells during activation but, in contrast to cancer, metabolic transitions in T cells are part of a physiological process. Currently, there is intense interest in understanding the cause and effect relationship between metabolic reprogramming and T cell differentiation. After the recent success of cancer immunotherapy, the crosstalk between immune system and cancer has come to the forefront of clinical and basic research. One of the key goals is to delineate how metabolic alterations of cancer influence metabolism-regulated function and differentiation of tumor resident T cells and how such effects might be altered by immunotherapy. Here, we review the unique metabolic features of cancer, the implications of cancer metabolism on T cell metabolic reprogramming during antigen encounters, and the translational prospective of harnessing metabolism in cancer and T cells for cancer therapy.