Microbial pathogenesis and type III interferons.
Microbial pathogenesis and type III interferons.
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微生物发病机制和 III 型干扰素。
DOI：
10.1016/j.cytogfr.2016.02.005
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发表时间：
2016-06
影响因子：
13
通讯作者：
Parker D
中科院分区：
文献类型：
--
作者：
Cohen TS;Parker D
人类III型IFN基因多态性可以预测患者的预后。被病毒和细菌病原体激活。临床数据和小鼠研究表明，III型IFN对感染有负面影响。III型IFN是宿主免疫调节的潜在靶点。先天免疫系统具有多种途径来感知和响应微生物病原体。一个这样的家族是干扰素（IFN），一个参与多种细胞功能的细胞因子家族。I型IFN被认为在几种病毒和细菌疾病中是重要的，而最近鉴定的III型IFN（IFNL 1、IFNL 2、IFNL 3、IFNL 4）主要在病毒感染的情况下进行研究。然而，病毒和细菌感染并不是相互排斥的，并且病毒病原体的存在通常会增加细菌感染的发病机制。III型IFN在细菌和病毒-细菌混合感染中的作用刚刚开始探索。在这篇迷你综述中，我们讨论了III型IFN信号及其在微生物发病机制中的作用，重点是已与细菌病原体进行的工作。
Human type III IFN polymorphisms can predict patient outcome. Activated by both viral and bacterial pathogens. Clinical data and mouse studies have shown a role for type III IFN in negatively contributing to infection. Type III IFN is a potential target for host immunomodulation. The innate immune system possesses a multitude of pathways to sense and respond to microbial pathogens. One such family are the interferons (IFNs), a family of cytokines that are involved in several cellular functions. Type I IFNs are appreciated to be important in several viral and bacterial diseases, while the recently identified type III IFNs (IFNL1, IFNL2, IFNL3, IFNL4) have been studied primarily in the context of viral infection. Viral and bacterial infections however are not mutually exclusive, and often the presence of a viral pathogen increases the pathogenesis of bacterial infection. The role of type III IFN in bacterial and viral-bacterial co-infections has just begun to be explored. In this mini review we discuss type III IFN signaling and its role in microbial pathogenesis with an emphasis on the work that has been conducted with bacterial pathogens.