Lithium-induced increase in human brain grey matter
Lithium-induced increase in human brain grey matter
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DOI：
10.1016/s0140-6736(00)02793-8
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发表时间：
2000-10-07
期刊：
影响因子：
168.9
通讯作者：
Menji, HK
中科院分区：
文献类型：
--
作者：
Moore, GJ;Bebchuk, JM;Menji, HK
啮齿动物研究表明，锂具有神经营养或神经保护作用。我们使用三维磁共振成像和脑分割来研究双相情感障碍患者长期使用锂药物引起的灰质体积增加。治疗4周后，灰质体积增加。灰质的增加可能是由于神经营养作用。
Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.