Changing prevalence of oral manifestations of human immunodeficiency virus in the era of protease inhibitor therapy
Changing prevalence of oral manifestations of human immunodeficiency virus in the era of protease inhibitor therapy
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DOI：
10.1016/s1079-2104(00)70092-8
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发表时间：
2000-03-01
期刊：
影响因子：
--
通讯作者：
Eron, JE
中科院分区：
文献类型：
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作者：
Patton, LL;McKaig, R;Eron, JE
Objective.本研究的目的是确定人类免疫缺陷病毒（HIV）口腔表现的流行趋势。连续招募的570名HIV感染的成年人进行了检查，使用既定的HIV相关口腔病变的推定临床标准。将广泛使用HIV蛋白酶抑制剂之前的口腔病变患病率（1995年2月至1996年8月，早期样本的8%，n = 271）与最近更广泛使用蛋白酶抑制剂期间的病变患病率（1996年12月至1999年2月，晚期样本的42%，n = 299）进行比较。口腔病变的总体患病率从早期到晚期显著降低，分别为47.6%至37.5%（P = 0.01），病变类型存在一定差异。毛状白斑（25.8%~ 11.4%; P <0.01）和坏死性牙周病（4.8%~ 1.7%; P = 0.03）患病率下降，而HIV唾液腺疾病患病率上升（1.8%~ 5.0%; P = 0.04）。口腔念珠菌病（20.3%~ 16.7%）、口腔溃疡（3.7%~ 3.0%）、口腔疣（2.2%~ 4.0%）、单纯疱疹病毒病变（1.8%~ 2.0%）和卡波西肉瘤（1.1%~ 0.3%）患病率的变化无统计学意义（所有比较P > 0.20）。在蛋白酶抑制剂使用的时代，口腔机会性感染的模式正在发生变化。
Objective. The purpose of this study was to determine temporal trends in the prevalence of oral manifestations of human immunodeficiency virus (HIV).Study design. Five hundred seventy HIV-infected adults recruited consecutively were examined by using established presumptive clinical criteria for HIV-associated oral lesions. Prevalence of oral lesions before the widespread use of HIV protease inhibitors (February 1995 through August 1996, 8% of the early sample, n = 271) was compared with lesion prevalence in a more recent period of greater protease inhibitor use (December 1996 through February 1999, 42% of the late sample, n = 299).Results. Overall prevalence of oral lesions significantly decreased from early to late periods, 47.6% to 37.5%, respectively (P = .01), with some variation by lesion type. Prevalence of hairy leukoplakia (25.8% to 11.4%; P < .01) and necrotizing periodontal diseases (4.8% to 1.7%; P = .03) decreased, whereas HIV salivary gland disease increased (1.8% to 5.0%; P = .04). Changes in prevalence of oral candidiasis (20.3% to 16.7%), aphthous ulcers (3.7% to 3.0%), oral warts (2.2% to 4.0%), herpes simplex virus lesions (1.8% to 2.0%), and Kaposi's sarcoma (1.1% to 0.3% were not statistically significant (P > .20 for all comparisons).Conclusion. The pattern of oral opportunistic infections is changing in the era of protease inhibitor use.