Sterically Congested Ester Formation from α-Substituted Malononitrile and Alcohol by an Oxidative Method Using Molecular Oxygen
Sterically Congested Ester Formation from α-Substituted Malononitrile and Alcohol by an Oxidative Method Using Molecular Oxygen
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DOI：
10.1002/ejoc.201800984
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发表时间：
2019-01-31
影响因子：
2.8
通讯作者：
Sakamoto, Daisuke
中科院分区：
文献类型：
--
作者：
Hayashi, Yujiro;Li, Jing;Sakamoto, Daisuke
通过在碱存在下在分子氧气氛下简单地混合α-取代丙二腈和醇或硫醇，开发了容易获得的取代丙二腈和醇或硫醇的无金属氧化酯化或硫代酯化。可以有效地制备空间位阻酯或硫酯。
A metal-free oxidative esterification or thio-esterification of readily available substituted malononitrile and alcohol or thiol has been developed by simply mixing alpha-substituted malononitrile and alcohol or thiol in the presence of base under a molecular oxygen atmosphere. Sterically hindered ester or thioester can be prepared efficiently.