A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins
A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins
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DOI：
10.1016/s0376-8716(99)00053-8
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发表时间：
1999-11-01
影响因子：
4.2
通讯作者：
Kendler, KS
中科院分区：
文献类型：
--
作者：
Hettema, JM;Corey, LA;Kendler, KS
过去几十年的许多流行病学研究一直表明，使用各种精神活性物质（合法和非法）之间存在积极联系。这种关联可能是由于共同的遗传和/或共同的环境风险因素。本研究使用多变量结构方程模型来确定烟草、酒精和咖啡因这三种最常见的精神活性物质的使用之间的协变来源。特别是，我们希望澄清遗传和环境风险因素在这三种物质中共享的程度，以及其影响的物质特异性。样本，包括收集的数据，从成员的人口为基础的弗吉尼亚州双胞胎登记处，包括774个单卵和809个双卵男性和女性双胞胎对。我们的研究结果表明，这三种物质之间共享的遗传和个体特定的环境因素占总方差的比例不大。例如，在男性和女性中，三种物质的共同遗传风险因素占责任总方差的7 - 28%，占遗传方差的12-56%。共同的家庭环境似乎起不了什么作用。潜在的遗传和个人环境风险因素产生的责任（多）物质使用一般的物质特异性因素也发挥了重要的病因作用。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
Numerous epidemiologic studies in the past few decades have consistently demonstrated positive associations between the use of various psychoactive substances, both licit and illicit. This association could be due to shared genetic and/or shared environmental risk factors. This study uses multivariate structural equation modeling to determine the sources of covariation between the use of tobacco, alcohol, and caffeine, the three most commonly consumed psychoactive substances. In particular, we wish to clarify the extent to which genetic and environmental risk factors are shared across these three substances versus are substance specific in their effect. The sample, consisting of data collected from members of the population-based Virginia Twin Registry, consists of 774 monozygotic and 809 dizygotic male and female twin pairs. Our results demonstrate that genetic and individual specific environmental factors that are shared between these three substances account for a modest proportion of the total variance. For example, shared genetic risk factors across the three substances in males and females account for between 7 and 28% of the total variance in liability and 12-56% of the genetic variance. Common familial environment appears to play little or no role. Underlying genetic and individual environmental risk factors produce liability to (poly)substance use in general; substance specific factors also play an important etiologic role. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.