Corticosteroid administration for patients with coronary artery aneurysms after Kawasaki disease may be associated with impaired regression
Corticosteroid administration for patients with coronary artery aneurysms after Kawasaki disease may be associated with impaired regression
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DOI：
10.1016/j.ijcard.2010.08.070
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发表时间：
2012-01-12
影响因子：
3.5
通讯作者：
McCrindle, Brian W.
中科院分区：
文献类型：
--
作者：
Millar, Kyle;Manlhiot, Cedric;McCrindle, Brian W.
简介：在川崎（KD）中使用皮质类固醇是有争议的，但对于对初始治疗无反应的患者可接受治疗。皮质类固醇对冠状动脉瘤（CAA）和未来血管重塑的影响尚不清楚。方法和结果：回顾了1990年至2008年KD后80例CAA患者（73%为男性;诊断时的中位年龄为2.2岁）的临床病史，其中19例（24%）在急性期接受了全身皮质类固醇（14例为非全身性皮质类固醇）。
Introduction: Corticosteroid administration in Kawasaki disease (KD) is controversial but accepted as treatment for patients who do not respond to initial treatment. The impact of corticosteroids on evolving coronary artery aneurysms (CAA) and future vascular remodelling is unknown.Methods and results: The clinical history of 80 patients (73% male; median age at diagnosis 2.2 years) seen from 1990 to 2008 with CAAs after KD were reviewed, 19 (24%) of whom received systemic corticosteroids in the acute phase (14 for