CHANGES IN THE EXTRACELLULAR-MATRIX OF THE HUMAN OPTIC-NERVE HEAD IN PRIMARY OPEN-ANGLE GLAUCOMA
CHANGES IN THE EXTRACELLULAR-MATRIX OF THE HUMAN OPTIC-NERVE HEAD IN PRIMARY OPEN-ANGLE GLAUCOMA
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DOI：
10.1016/s0002-9394(14)75984-7
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发表时间：
1990-02-15
影响因子：
4.2
通讯作者：
NEUFELD, AH
中科院分区：
文献类型：
--
作者：
HERNANDEZ, MR;ANDRZEJEWSKA, WM;NEUFELD, AH
使用免疫荧光染色，我们能够表征组成的大分子的组成和分布的变化？筛板的青光眼的人视神经乳头的细胞外基质。在肿瘤杯附近的组织中，筛板核心内的弹性蛋白纤维明显紊乱和丢失。VI型胶原蛋白，通常稀疏，在数量上大大增加，在整个筛板在青光眼的眼睛与所有程度的损害。IV型胶原蛋白和其他基底膜大分子似乎延伸到神经束中，推测填充在先前由神经占据的空间中。板后区无明显变化，这表明筛板细胞外基质变化的特异性。我们的研究结果表明，细胞外基质的变化发挥了重要的作用，在进展中的脑水肿的过程中，可能是一个致病因子的疾病。
Using immunofluorescent staining, we were able to characterize the changes in composition and distribution of the macromolecules making up the extracellular matrix of the lamina cribrosa of the glaucomatous human optic nerve head. In tissue adjacent to the glaucomatous cups, there was marked disorganization and loss of fibers of elastin within the cores of the cribriform plates. Collagen type VI, normally sparse, increased in quantity considerably throughout the lamina cribrosa in glaucomatous eyes with all degrees of damage. Collagen type IV and other basement membrane macromolecules appeared to extend into nerve bundles, presumably filling in spaces previously occupied by nerves. There was no appreciable change in the postlaminar region, which indicates the specificity of the extracellular matrix changes in the lamina cribrosa. Our results indicate that changes in the extracellular matix play an important role in the progression of the glaucomatous process and may be a causative agent of the disease.