Evolution of the Aza-Diels-Alder Reaction of 2H-Azirines
Evolution of the Aza-Diels-Alder Reaction of 2H-Azirines
复制标题
2H-氮丙啶的 Aza-Diels-Alder 反应的演变
DOI：
10.1055/s-0035-1562493
复制
发表时间：
2016
期刊：
影响因子：
2
通讯作者：
Xu Hua-Dong
中科院分区：
文献类型：
--
作者：
Zhou Hao;Shen Mei-Hua;Xu Hua-Dong
The aza-Diels–Alder reaction of 2H-azirines with 1,3-dienes provides facile access to the structurally intriguing and difficult to access 1-azabicyclo[4.1.0]hept-3-ene scaffold. Its application in organic synthesis and medicinal chemistry is heavily hampered by the narrow substrate scope for both reacting partners. Herein, the discovery and exploration of this reaction are summarized and discussed. A recent breakthrough is an intramolecular version that overcomes the limitations of conventional methods.
