TISSUE DISTRIBUTION OF ANTI-TUMOR DRUGS ASSOCIATED WITH POLYALKYLCYANOACRYLATE NANOPARTICLES
TISSUE DISTRIBUTION OF ANTI-TUMOR DRUGS ASSOCIATED WITH POLYALKYLCYANOACRYLATE NANOPARTICLES
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DOI：
10.1002/jps.2600690222
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发表时间：
1980-01-01
影响因子：
3.8
通讯作者：
SPEISER, P
中科院分区：
文献类型：
--
作者：
COUVREUR, P;KANTE, B;SPEISER, P
聚氰基丙烯酸甲酯纳米粒，聚氰基丙烯酸乙酯纳米粒，游离3 H-放线菌素D和3 H-长春碱进行了研究，重点是它们在大鼠组织中的分布模式后，静脉注射。细胞生长抑制药物在聚氰基丙烯酸烷基酯纳米粒上的吸附可以改变药物在组织中的分布。特别是对于长春碱，药物处置的改变是重要的。数据给出有关的纳米颗粒-药物复合物的形成和稳定性。聚氰基丙烯酸烷基酯纳米粒由于其尺寸、结构、可降解性和药物吸附性而成为一种有趣的药物载体。
Polymethylcyanoacrylate nanoparticles, polyethylcyanoacrylate nanoparticles, and free 3H-dactinomycin and 3H-vinblastine were studied with emphasis on their distribution pattern in rat tissues after i.v. administration. The adsorption of cytostatic drugs to polyalkylcyanoacrylate nanoparticles can modify drug distribution in tissues. Particularly with vinblastine, modification of drug disposition is important. Data are given concerning the formation and stability of nanoparticle-drug complexes. Polyalkylcyanoacrylate nanoparticles seem to be an interesting drug carrier owing to their size, structure, degradability and drug sorptive properties.