Interference Effects of Deleterious and Beneficial Mutations in Large Asexual Populations
Interference Effects of Deleterious and Beneficial Mutations in Large Asexual Populations
复制标题
DOI：
10.1534/genetics.119.301960
复制
发表时间：
2019-04-01
期刊：
影响因子：
3.3
通讯作者：
Jain, Kavita
中科院分区：
文献类型：
--
作者：
Jain, Kavita
已知有益突变和有害突变的连锁会降低大型无性群体中有利突变的固定概率。虽然强有害突变对适应性进化的阻碍作用已经得到了很好的研究，但弱有害突变，无论是孤立的还是与上级有益突变一起，如何影响适应的速度还没有得到充分的探讨。当对有害突变的选择较弱时，有益突变体可以在许多遗传背景中固定，在这里，考虑到这一因素，我得到了一个精确的解析表达式，在一个无性群体中的突变选择平衡的固定概率。然后，我利用这一结果沿着与克隆干扰理论，以调查的联合作用的有益和有害的突变的适应率，并确定参数区域，它是减少由于干扰的有益或有害或两种类型的突变。我还研究了适应无性种群的突变率的演变，发现相关的有益突变比有害突变对增变因子固定的影响更大。
Linked beneficial and deleterious mutations are known to decrease the fixation probability of a favorable mutation in large asexual populations. While the hindering effect of strongly deleterious mutations on adaptive evolution has been well studied, how weakly deleterious mutations, either in isolation or with superior beneficial mutations, influence the rate of adaptation has not been fully explored. When the selection against the deleterious mutations is weak, the beneficial mutant can fix in many genetic backgrounds, besides the one it arose on. Here, taking this factor into account, I obtain an accurate analytical expression for the fixation probability of a beneficial mutant in an asexual population at mutation-selection balance. I then exploit this result along with clonal interference theory to investigate the joint effect of linked beneficial and deleterious mutations on the rate of adaptation, and identify parameter regions where it is reduced due to interference by either beneficial or deleterious or both types of mutations. I also study the evolution of mutation rates in adapting asexual populations, and find that linked beneficial mutations have a stronger influence than the deleterious mutations on mutator fixation.