Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices
Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices
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基于血浆指标的银杏叶提取物对阿托伐他汀药代动力学和疗效的影响
DOI：
10.3109/00498254.2012.661100
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发表时间：
2012-08-01
期刊：
影响因子：
1.8
通讯作者：
Zhou, Hong-Hao
中科院分区：
文献类型：
--
作者：
Guo, Cheng-Xian;Pei, Qi;Zhou, Hong-Hao
银杏叶提取物（GBE）是世界上使用最广泛的草药之一。它通常与他汀类药物联合使用以治疗疾病，特别是一些神经系统疾病。我们的目的是调查GBE对阿托伐他汀的药代动力学和疗效的影响，目前尚不清楚。16名志愿者接受40 mg阿托伐他汀单次口服给药，随后为至少5天的洗脱期。然后志愿者每天服用360 mg GBE，持续14天，然后单次服用40 mg阿托伐他汀。在阿托伐他汀摄入后48小时内获得的系列血液样品进行阿托伐他汀血浆浓度和胆固醇合成（豆甾醇）和胆固醇吸收（谷甾醇）的标志物的测定。GBE给药后，阿托伐他汀的AUC 0 -48、AUC 0-∞和Cmax分别降低14.27%（p = 0.005）、10.00%（p = 0.03）和28.93%（p = 0.002）;阿托伐他汀的Vd/F和CL/F分别增加31.95%（p = 0.017）和6.48%（p = 0.044）。治疗14天后，GBE对阿托伐他汀的降胆固醇疗效无显著影响。这项研究表明，GBE轻微降低血浆阿托伐他汀浓度，但对阿托伐他汀的降胆固醇疗效没有有意义的影响。
Ginkgo biloba extract (GBE) is one of the most widely used herbal medicines in the world. It is often administered in combination with statins to treat diseases, especially some nervous system disorders. We aimed to investigate the influences of GBE on pharmacokinetics and efficacy of atorvastatin, which are currently unclear. Sixteen volunteers received a single oral dose of 40 mg atorvastatin, followed by a wash-out period of at least 5 days. Then the volunteers took 360 mg GBE daily for 14 days, followed by a single dose of 40 mg atorvastatin. Serial blood samples obtained over a period of 48 h after atorvastatin ingestion were subjected to determination of atorvastatin plasma concentrations and markers of cholesterol synthesis (lathosterol) and cholesterol absorption (sitosterol). With GBE administration, AUC0–48, AUC0–∞ and Cmax of atorvastatin were reduced by 14.27% (p = 0.005), 10.00% (p = 0.03) and 28.93% (p = 0.002), respectively; Vd/F and CL/F of atorvastatin were increased by 31.95% (p = 0.017) and 6.48% (p = 0.044). After 14 days of treatment, GBE has no significant effects on cholesterol-lowering efficacy of atorvastatin. This study suggests that GBE slightly decreases the plasma atorvastatin concentrations, but has no meaningful effect on the cholesterol-lowering efficacy of atorvastatin.