Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2
Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2
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DOI：
10.1016/s0090-6980(02)00028-x
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发表时间：
2002-08-01
影响因子：
2.9
通讯作者：
Langenbach, R
中科院分区：
文献类型：
--
作者：
Loftin, CD;Tiano, HF;Langenbach, R
缺乏环氧合酶-1（考克斯-1）或考克斯-2的小鼠以及缺乏两种考克斯亚型的小鼠的发育提供了阐明这些酶的生理和病理生理作用的模型。COX缺陷小鼠的研究结果表明，考克斯-2可能比考克斯-1更重要的是提供前列腺素（PG），以维持组织的稳态。此外，这两种亚型都可能参与疾病的发展，如炎症和癌症。因此，每种亚型对疾病预防或发展的贡献比最初描述的更复杂。对考克斯缺陷小鼠的研究表明，除了考克斯-2选择性抑制外，使用无胃肠道副作用的考克斯-1选择性抑制剂也可以取得治疗进展。(C)2002年由Elsevier Science Inc.出版
The development of mice deficient in either cyclooxygenase-1 (COX-1) or COX-2, as well as mice deficient in both COX isoforms, has provided models to elucidate the physiological and pathophysiological roles of these enzymes. The findings obtained with the COX-deficient mice suggest that COX-2 may be more important than COX-1 for supplying prostaglandins (PGs) to maintain tissue homeostasis. Furthermore, both isoforms may be involved in the development of diseases, such as inflammation and cancer. Therefore, the contribution of each isoform to the prevention or development of disease is more complex than originally described. Studies with the COX-deficient mice suggest that in addition to COX-2-selective inhibition, therapeutic advances may also be achieved with COX-1-selective inhibitors which lack gastrointestinal side effects. (C) 2002 Published by Elsevier Science Inc.