RESECTION OF HEPATOCELLULAR CARCINOMAS - RESULTS IN 72 EUROPEAN PATIENTS WITH CIRRHOSIS
RESECTION OF HEPATOCELLULAR CARCINOMAS - RESULTS IN 72 EUROPEAN PATIENTS WITH CIRRHOSIS
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DOI：
10.1016/0016-5085(90)90296-d
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发表时间：
1990-03-01
期刊：
影响因子：
29.4
通讯作者：
DELLEPIANE, M
中科院分区：
文献类型：
--
作者：
FRANCO, D;CAPUSSOTTI, L;DELLEPIANE, M
这项研究是为了确定欧洲肝硬变患者肝细胞癌切除的结果，采用与东方相同的肿瘤检测、外科处理和病理学标准。72名患者接受了肝脏切除。1年和3年生存率分别为68%和51%。儿童‘’S/普格‘’S A级患者的生存率显著高于B-C级患者。肿瘤包膜较厚的患者比浸润性肿瘤患者存活时间更长，而且癌症复发率明显较低。包膜较厚的A级肝细胞癌患者的3年生存率为77%。肿瘤的大小或症状的出现与生存无关。这些数据表明，在欧洲肝硬变患者中切除肝细胞癌可以取得良好的效果。包膜较厚的肿瘤和足够的肝功能是低复发率和高存活率的主要决定因素。这一系列的临床结果与东方报道的相似。
This study was undertaken to determine the results of resection of hepatocellular carcinoma in cirrhotic patients in Europe, using the same criteria as in the Orient for detection, surgical management, and pathology of the tumors. Seventy-two patients had a liver resection. One- and 3-yr survival rates were 68% and 51% respectively. Survival rate was significantly higher in Child''s/Pugh''s class A than in class B-C patients. Patients with a thickly encapsulated tumor lived longer than those with an infiltrating tumor and had in addition a significantly lower incidence of cancer recurrence. Class A patients with a thickly encapsulated hepatocellular carcinoma had a 77% 3-year survival rate. There was no relation between the size of the tumor or the presence of symptoms and survival. These data suggest that good results can be achieved by resection of hepatocellular carcinomas in European cirrhotic patients. A thickly encapsulated tumor and an adequate liver function are the main determinants of low cancer recurrence and high survival. The clinical results in this series are similar to those reported from the Orient.