gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism
gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism
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gp91(phox) 是一种评估氧化应激的新型生物标志物，在亚临床甲状腺功能减退症中升高
DOI：
10.1155/2020/3161730
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发表时间：
2020-05-06
影响因子：
2.8
通讯作者：
Zhou, Xiaoming
中科院分区：
文献类型：
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作者：
Ma, Xiaochun;Wang, Furong;Zhou, Xiaoming
背景。 gp91(phox) 是 NADPH 氧化酶 (NOX) 的催化核心和 NOX 活化的生物标志物，最近在多项研究中被认为是全身氧化应激的参数。亚临床甲状腺功能减退症（SH）的特征是血清促甲状腺激素（TSH）水平升高，并且经常伴有胆固醇血症。本研究通过测定血清可溶性 gp91(phox) 水平来评估 SH 患者的氧化应激情况。并研究了gp91(phox)、低密度脂蛋白-C(LDL-C)和TSH之间的关系。方法。共有 51 名受试者被纳入研究，并分为四组：健康对照受试者（n = 13）、单独高 LDL-C 水平对照者（n = 12）、LDL-C 水平正常的 SH（n = 11）和 LDL-C 水平高的 SH（n = 15）。收集相关临床和实验室数据进行统计分析。所有患者均为初诊，未服用任何药物。提取血脂和甲状腺功能信息，并通过ELISA获得gp91phox浓度。结果。 LDL-C水平较高的SH患者（81.52±37.00ug/mL）血清中可溶性gp91phox水平较健康对照（54.98±1.83ug/mL）明显升高，p
Background. gp91(phox), the catalytic core of NADPH oxidase (NOX) and biomarker of NOX activation, has been recently recognized as a parameter of systemic oxidative stress in several studies. Subclinical hypothyroidism (SH) is characteristic of elevated level of serum thyroid stimulating hormone (TSH) and is frequently accompanied with cholesterolemia. In this study, the levels of serum soluble gp91(phox) were measured to assess the oxidative stress in patients with SH. And the relationship among gp91(phox), low-density lipoprotein-C (LDL-C), and TSH was also investigated. Methods. A total of 51 subjects were enrolled and categorized into four groups: the healthy controls subjects (n = 13), controls with high level of LDL-C alone (n = 12), SH with normal level of LDL-C (n = 11), and SH with high level of LDL-C (n = 15). The related clinical and laboratory data were collected for statistical analysis. All the patients were newly diagnosed and did not take any medication. The information of lipid profile and thyroid function was extracted, and the concentrations of gp91phox were obtained with ELISA. Results. The levels of serum soluble gp91phox evidently increased in the patients with SH with a high level of LDL-C (81.52 +/- 37.00 ug/mL) as compared to the healthy controls (54.98 +/- 1.83ug/mL, p