PRELIMINARY-STUDY OF MAGNETIC-RESONANCE-IMAGING CHARACTERISTICS IN 8-YEAR-OLDS TO 16-YEAR-OLDS WITH MANIA
PRELIMINARY-STUDY OF MAGNETIC-RESONANCE-IMAGING CHARACTERISTICS IN 8-YEAR-OLDS TO 16-YEAR-OLDS WITH MANIA
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DOI：
10.1097/00004583-199506000-00014
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发表时间：
1995-06-01
影响因子：
13.3
通讯作者：
LEE, BCP
中科院分区：
文献类型：
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作者：
BOTTERON, KN;VANNIER, MW;LEE, BCP
目的：根据DSM-III-R标准，探讨躁狂症儿童和青少年的磁共振成像（MRI）特征。方法：采用《学龄期儿童情感障碍与精神分裂症量表-现发作版》、《儿童总体评估量表》和《家族史-研究诊断标准》对8- 16岁躁狂（n = 10）和正常（n = 5）的连续参考样本进行评估。对未服用镇静剂的受试者进行MRI扫描，使用1.5 T磁共振扫描仪获得t1加权冠状和矢状图像以及t2加权轴向图像。通过盲临床解释、t -2加权深白质高信号和花瓣评分、计算机辅助心室和脑容量分析对图像进行评估。结果：10名躁狂受试者中有8名完成了扫描，5名对照组完成了扫描。4名躁狂患者和1名对照患者的扫描显示脑室或白质异常。重要的发现是，年龄的增长与左右心室容量呈正相关。8例躁狂患者中有2例出现汇合性皮层下高信号。结论：MRI脑扫描在8 ~ 16岁儿童中是可行的。临床解释和结构化评分的初步结果表明，年轻躁狂和正常受试者之间存在结构性差异。为了更好地描述差异，需要对更大的样本进行调查。
Objective: To examine magnetic resonance imaging (MRI) characteristics in children and adolescents with mania according to DSM-III-R criteria. Method: A convenience sample of consecutively referred 8- to 16-year-old manic (n = 10) and normal (n = 5) subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present Episode Version, the Children's Global Assessment Scale, and the Family History-Research Diagnostic Criteria. MRI scans were obtained from unsedated subjects using a 1.5 T MR scanner to acquire T-1-weighted coronal and sagittal images and T-2-weighted axial images. Images were assessed by blind clinical interpretation, ratings of T-2-weighted deep white matter hyperintensities and petalia, and computer-assisted volumetric analysis of ventricular and cerebral volumes. Results: Eight of 10 manic subjects and all 5 controls completed the scans. Scans of 4 manic subjects and 1 control subject showed ventricular or white matter abnormalities by clinical interpretation. Significant findings were positive correlations between increasing age and both right and left ventricular volumes. Two of the 8 manic subjects and no controls had confluent subcortical hyperintensities. Conclusions: MRI brain scanning was feasible in 8- to 16-year-olds. Preliminary findings from clinical interpretations and structured ratings suggest structural differences between young manic and normal subjects. Investigations of larger samples are needed to better characterize the differences.