An ecological approach to assessing the epidemiology of antimicrobial resistance in animal and human populations
An ecological approach to assessing the epidemiology of antimicrobial resistance in animal and human populations
复制标题
DOI：
10.1098/rspb.2011.1975
复制
发表时间：
2012-04-22
影响因子：
4.7
通讯作者：
Reid, Stuart W. J.
中科院分区：
文献类型：
--
作者：
Mather, Alison E.;Matthews, Louise;Reid, Stuart W. J.
我们研究了长期监测数据的抗菌药物耐药性（AMR）鼠伤寒沙门氏菌DT104（DT104）分离株同时采样和同域的人类和动物种群在苏格兰。使用新的生态学和流行病学的方法来研究多样性，表型和时间相关性的电阻配置文件，我们评估了更可能的来源，这两个人口的电阻。AMR表型的生态多样性是显着更大的人类分离株比动物分离株，在样本和人口的分辨率。在5200株分离株中，有65种耐药表型，13种为动物特有，30种为人类特有，22种为两者共有。在这22种中，11种首先在人类分离株中鉴定，而只有5种首先在动物分离株中鉴定。我们的结论是，虽然生态连接，动物和人类有区别的DT 104社区，不同的流行，联系和多样性。此外，我们推断，同域动物种群不太可能是人类抗性多样性的主要来源。这表明，目前的政策强调限制抗生素在家畜中的使用可能过于简单化。虽然这些结论适用于苏格兰的DT 104，但这种方法也适用于其他细菌宿主生态系统中的AMR。
We examined long-term surveillance data on antimicrobial resistance (AMR) in Salmonella Typhimurium DT104 (DT104) isolates from concurrently sampled and sympatric human and animal populations in Scotland. Using novel ecological and epidemiological approaches to examine diversity, and phenotypic and temporal relatedness of the resistance profiles, we assessed the more probable source of resistance of these two populations. The ecological diversity of AMR phenotypes was significantly greater in human isolates than in animal isolates, at the resolution of both sample and population. Of 5200 isolates, there were 65 resistance phenotypes, 13 unique to animals, 30 unique to humans and 22 were common to both. Of these 22, 11 were identified first in the human isolates, whereas only five were identified first in the animal isolates. We conclude that, while ecologically connected, animals and humans have distinguishable DT104 communities, differing in prevalence, linkage and diversity. Furthermore, we infer that the sympatric animal population is unlikely to be the major source of resistance diversity for humans. This suggests that current policy emphasis on restricting antimicrobial use in domestic animals may be overly simplistic. While these conclusions pertain to DT104 in Scotland, this approach could be applied to AMR in other bacteria-host ecosystems.