Chronic wound pathogenesis and current treatment strategies: A unifying hypothesis
Chronic wound pathogenesis and current treatment strategies: A unifying hypothesis
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DOI：
10.1097/01.prs.0000225431.63010.1b
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发表时间：
2006-06-01
影响因子：
3.6
通讯作者：
Kloeters, Oliver
中科院分区：
文献类型：
--
作者：
Mustoe, Thomas A.;O'Shaughnessy, Kristina;Kloeters, Oliver
大多数慢性伤口可分为三种主要类型：压力溃疡、静脉溃疡和糖尿病溃疡。作者提出了一个基于四个主要致病因素的慢性伤口发病机制的统一假设：局部组织缺氧，伤口细菌定植，反复缺血再灌注损伤，以及老年患者细胞和全身应激反应的改变。治疗慢性伤口的传统策略已显示出有限的成功。作者探索了专门针对慢性伤口发病机制的每个个体决定因素的潜在治疗方案。此外，他们还探索了一种联合治疗方法，共同靶向慢性伤口病理学的所有组成部分。这些创新的想法和疗法可能会引起临床医生和研究人员的极大兴趣，同时进一步为慢性伤口患者提供显着的益处。
Most chronic wounds can be classified into three major types: pressure ulcers, venous ulcers, and diabetic ulcers. The authors propose a unifying hypothesis of chronic wound pathogenesis based on four main causative factors: local tissue hypoxia, bacterial colonization of the wound, repetitive ischemia-reperfusion injury, and an altered cellular and systemic stress response in the aged patient. Traditional strategies for the treatment of chronic wounds have shown limited success. The authors explore potential treatment regimens specifically aimed at each individual determinant of chronic wound pathogenesis. Furthermore, they explore a combined therapeutic approach that collectively targets all the components of chronic wound pathology. These innovative ideas and therapies could be of substantial interest for clinicians and researchers, while further offering significant benefit to patients with chronic wounds.